Neelam V. Desai, MD - Harvard Health

Dr. Neelam Desai

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Levine Cancer Institute

Studies Breast Cancer
Studies Breast cancer
6 reported clinical trials
13 drugs studied

Area of expertise

1Breast Cancer
Neelam Desai has run 6 trials for Breast Cancer. Some of their research focus areas include:
HER2 positive
HER2 negative
ER positive
2Breast Cancer
Neelam Desai has run 4 trials for Breast cancer. Some of their research focus areas include:
HER2 positive
HER2 negative
ER negative

Affiliated Hospitals

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Levine Cancer Institute
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Beth Israel Deaconess Medical Center

Clinical Trials Neelam Desai is currently running

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CDK4/6 Inhibitors

for Metastatic Breast Cancer

The purpose of this study is to generate evidence on an alternative dosing strategy for CDK4/6 inhibitors to help more patients with Metastatic Breast Cancer (MBC) (age ≥ 65 years) tolerate side effects and stay on treatment longer, to derive the most clinical benefit from these drugs. The primary objective of the CDK Study is to compare time to treatment discontinuation (TTD) on the approved dosing for palbociclib (125 mg orally daily on days 1-21 of 28-day cycle) or ribociclib (600 mg orally daily on days 1-21 of 28-day cycle) vs. TTD using titrated dosing approach with the same schedule but starting at a lower dose of palbociclib (100 mg or 75 mg) or ribociclib (400 mg or 200 mg) and escalating the dose if well-tolerated in combination with provider/patient choice endocrine therapy (aromatase inhibitor (AI) or fulvestrant) in patients age 65 or older with HR+/HER2- MBC. The secondary and exploratory objectives will generate evidence needed to personalize treatment decisions by comparing patient-centric secondary outcomes and evaluating baseline factors. Together with their treating physician, participants will choose the CDK4/6 inhibitor (palbociclib or ribociclib) and which endocrine therapy (aromatase inhibitor or fulvestrant) of their choice but will be randomized to either Arm 1 (indicated dosing) or Arm 2 (titrated dosing). Note: Telehealth visits are allowed at any time per institutional guidelines. In addition, the study allows for remote consenting per institutional guidelines.
Recruiting2 awards Phase 33 criteria
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Sacituzumab Govitecan + Pembrolizumab

for Breast Cancer

This research study is studying to evaluate sacituzumab govitecan for individuals with localized triple negative breast cancer (TNBC) The names of the study drugs involved in this study is: * Sacituzumab govitecan (SG) * Pembrolizumab (combination therapy with SG)
Recruiting2 awards Phase 211 criteria

More about Neelam Desai

Clinical Trial Related1 year of experience running clinical trials · Led 6 trials as a Principal Investigator · 3 Active Clinical Trials
Treatments Neelam Desai has experience with
  • Pertuzumab
  • Trastuzumab
  • Pembrolizumab
  • Sacituzumab Govitecan
  • ADJUVANT ENDOCRINE THERAPY
  • Palbociclib

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