Dr. Naida M Cole, MD

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University of Chicago

Studies Cesarean Section Complications
Studies Postpartum Hemorrhage
2 reported clinical trials
2 drugs studied

Affiliated Hospitals

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University Of Chicago

Clinical Trials Naida M Cole, MD is currently running

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Durometer

for Uterine Tone During Cesarean Section

This study will evaluate the use of a durometer to measure uterine tone in parturients undergoing cesarean delivery.
Recruiting1 award N/A
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Deuterated Oxytocin

for Postpartum Hemorrhage

Oxytocin is the first-line drug to promote contraction of the uterus and prevent atony immediately after delivery. Nonetheless, unpredictable uterine atony refractory to oxytocin affects roughly 250,000 parturients annually in the U.S. and rates are increasing. This two-part study will measure the action of oxytocin at cesarean delivery. The first part will measure the pharmacokinetics of a single intravenous (IV) dose of deuterium-labeled oxytocin. The second part will measure the pharmacodynamics of all plasma oxytocin to see how concentrations correspond to the contractile effect on the uterus. After delivery of the fetus, study subjects will receive a bolus of IV deuterated oxytocin followed by an unlabeled oxytocin infusion. Venous blood samples drawn at multiple time points (within 1 hour after delivery) will be analyzed for plasma concentrations of labeled and unlabeled (endogenous + exogenous infused) oxytocin over time. Plasma concentrations will be compared with 0-10 uterine tone scores measuring uterine contraction strength, to describe the concentration-effect relationship. The goal of this study is to define both the pharmacokinetics and pharmacodynamics of oxytocin in parturients to help identify the cause(s) of failed first-line oxytocin therapy.
Recruiting1 award Phase 2

More about Naida M Cole, MD

Clinical Trial Related1 year of experience running clinical trials · Led 2 trials as a Principal Investigator · 2 Active Clinical Trials
Treatments Naida M Cole, MD has experience with
  • Deuterated Oxytocin
  • Shore Durometer

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