Dr. Nadav L. Kastle
Claim this profileMaine Children's Cancer Program
Studies Cancer
Studies Blood Cancers
4 reported clinical trials
10 drugs studied
Affiliated Hospitals
Clinical Trials Nadav L. Kastle is currently running
Selinexor + Radiation
for Brain Cancer
This trial tests the safety and effectiveness of combining selinexor with radiation therapy in children and young adults with aggressive brain tumors. Selinexor is a drug that blocks a protein to stop cancer cells from growing. The study aims to find the best dose and see if this combination can shrink tumors.
Recruiting1 award Phase 1 & 21 criteria
Brentuximab Vedotin + Nivolumab
for Hodgkin's Lymphoma
This phase III trial compares the effect of adding immunotherapy (brentuximab vedotin and nivolumab) to standard treatment (chemotherapy with or without radiation) to the standard treatment alone in improving survival in patients with stage I and II classical Hodgkin lymphoma. Brentuximab vedotin is in a class of medications called antibody-drug conjugates. It is made of a monoclonal antibody called brentuximab that is linked to a cytotoxic agent called vedotin. Brentuximab attaches to CD30 positive lymphoma cells in a targeted way and delivers vedotin to kill them. A monoclonal antibody is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs such as doxorubicin hydrochloride, bleomycin sulfate, vinblastine sulfate, dacarbazine, and procarbazine hydrochloride work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Cyclophosphamide is in a class of medications called alkylating agents. It works by damaging the cell's deoxyribonucleic acid (DNA) and may kill cancer cells. It may also lower the body's immune response. Etoposide is in a class of medications known as podophyllotoxin derivatives. It blocks a certain enzyme needed for cell division and DNA repair and may kill cancer cells. Vincristine is in a class of medications called vinca alkaloids. It works by stopping cancer cells from growing and dividing and may kill them. Prednisone is in a class of medications called corticosteroids. It is used to reduce inflammation and lower the body's immune response to help lessen the side effects of chemotherapy drugs. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Adding immunotherapy to the standard treatment of chemotherapy with or without radiation may increase survival and/or fewer short-term or long-term side effects in patients with classical Hodgkin lymphoma compared to the standard treatment alone.
Recruiting2 awards Phase 3
More about Nadav L. Kastle
Clinical Trial Related3 years of experience running clinical trials · Led 4 trials as a Principal Investigator · 2 Active Clinical TrialsTreatments Nadav L. Kastle has experience with
- Multi-component Mobile Health And Social Media Physical Activity Intervention
- Wearing A Physical Activity Tracker Alone
- Radiation Therapy
- Selinexor
- Memantine Hydrochloride
- Brentuximab Vedotin
Breakdown of trials Nadav L. Kastle has run
Blood Cancers
Brain Tumor
Malignant Glioma
Brain Cancer
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Nadav L. Kastle specialize in?
Nadav L. Kastle focuses on Cancer and Blood Cancers. In particular, much of their work with Cancer has involved treating patients, or patients who are undergoing treatment.
Is Nadav L. Kastle currently recruiting for clinical trials?
Yes, Nadav L. Kastle is currently recruiting for 2 clinical trials in Scarborough Maine. If you're interested in participating, you should apply.
Are there any treatments that Nadav L. Kastle has studied deeply?
Yes, Nadav L. Kastle has studied treatments such as Multi-component mobile health and social media physical activity intervention, Wearing a physical activity tracker alone, Radiation Therapy.
What is the best way to schedule an appointment with Nadav L. Kastle?
Apply for one of the trials that Nadav L. Kastle is conducting.
What is the office address of Nadav L. Kastle?
The office of Nadav L. Kastle is located at: Maine Children's Cancer Program, Scarborough, Maine 04074 United States. This is the address for their practice at the Maine Children's Cancer Program.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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