Dr. Michael Osborne, MD

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Massachusetts General Hospital

Studies Pneumonia
Studies Atherosclerosis
3 reported clinical trials
3 drugs studied

Affiliated Hospitals

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Massachusetts General Hospital

Clinical Trials Michael Osborne, MD is currently running

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Noise Canceling Earplugs

for Heart Health

Noise from cars, planes, and trains affects all people and has been associated with heart disease. Almost 30% of Americans are exposed to harmful levels of noise and noise accounts for the loss of more than one million healthy life years per year in Europe. Noise causes stress and may be most dangerous when it happens at night. The mechanisms linking noise to heart disease involve changes in the brain and the "fight or flight" response. These changes lead to inflammation and blood vessel disease. However, there are few laws that restrict noise and it is not addressed in medical care. Further, as cities and industries grow, noise continues to increase. Moreover, noise often occurs in areas that are also exposed to other stressors like high air pollution and low income. Yet, there is little research on noise, and it is not known if lowering noise exposure helps heart health. The investigators will use imaging to test if earplugs that block noise improve stress symptoms and changes in the the brain, blood vessels, and stress pathways that lead to disease. The investigators expect that people who use earplugs will have lower measures of stress and heart disease at follow-up. The study will include 26 people with heart disease risk with high noise exposure or who are annoyed by noise. At the first visit, subjects will have imaging of the brain and blood vessels and will have assessments of stress, inflammation, and the "fight or flight" response. They will be assigned to use earplugs or not after the first visit. After 6 months, imaging and other testing will be repeated. It will help to understand how noise impacts the body and whether the effects can be changed. It may also identify important treatments to prevent heart disease in people exposed to noise. By testing if the adverse effects of noise can be lowered with earplugs, this project supports the AHA's mission to be a force for a world of longer and healthier lives.

Recruiting

0 awards

N/A

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Mindfulness

for Coronary Artery Disease

This study aims to evaluate the effect of 8 weeks of a stress reduction intervention on atherosclerotic plaque inflammation in adults with stable coronary artery disease, as quantified by positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) in individuals with increased psychosocial stress.

Recruiting

1 award

N/A

9 criteria

More about Michael Osborne, MD

Clinical Trial Related

1 year of experience running clinical trials · Led 3 trials as a Principal Investigator · 3 Active Clinical Trials

Treatments Michael Osborne, MD has experience with

  • Stress Reduction
  • Cognitive Processing Therapy
  • Noise Canceling Earplugs

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