Dr. Michael Burke, MD
Claim this profileChildren's Hospital of Wisconsin
Studies Leukemia
Studies Burkitt Lymphoma
14 reported clinical trials
43 drugs studied
Area of expertise
1Leukemia
BCR-ABL1 fusion positive
ABL-class fusion positive
CD123 positive
2Burkitt Lymphoma
BCR-ABL1 fusion positive
ABL-class fusion positive
Philadelphia chromosome positive
Affiliated Hospitals
Clinical Trials Michael Burke, MD is currently running
Venetoclax Combination Therapy
for Acute Myeloid Leukemia
The investigator is testing the addition of venetoclax to 5-azacitidine and vorinostat followed by standard chemotherapy to enhance treatment response in AML patients.
Recruiting3 awards Phase 1
Inotuzumab Ozogamicin
for Acute Lymphoblastic Leukemia
This phase III trial studies whether inotuzumab ozogamicin added to post-induction chemotherapy for patients with High-Risk B-cell Acute Lymphoblastic Leukemia (B-ALL) improves outcomes. This trial also studies the outcomes of patients with mixed phenotype acute leukemia (MPAL), and B-lymphoblastic lymphoma (B-LLy) when treated with ALL therapy without inotuzumab ozogamicin. Inotuzumab ozogamicin is a monoclonal antibody, called inotuzumab, linked to a type of chemotherapy called calicheamicin. Inotuzumab attaches to cancer cells in a targeted way and delivers calicheamicin to kill them. Other drugs used in the chemotherapy regimen, such as cyclophosphamide, cytarabine, dexamethasone, doxorubicin, daunorubicin, methotrexate, leucovorin, mercaptopurine, prednisone, thioguanine, vincristine, and pegaspargase or calaspargase pegol work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This trial will also study the outcomes of patients with mixed phenotype acute leukemia (MPAL) and disseminated B lymphoblastic lymphoma (B-LLy) when treated with high-risk ALL chemotherapy. The overall goal of this study is to understand if adding inotuzumab ozogamicin to standard of care chemotherapy maintains or improves outcomes in High Risk B-cell Acute Lymphoblastic Leukemia (HR B-ALL). The first part of the study includes the first two phases of therapy: Induction and Consolidation. This part will collect information on the leukemia, as well as the effects of the initial treatment, to classify patients into post-consolidation treatment groups. On the second part of this study, patients with HR B-ALL will receive the remainder of the chemotherapy cycles (interim maintenance I, delayed intensification, interim maintenance II, maintenance), with some patients randomized to receive inotuzumab. The patients that receive inotuzumab will not receive part of delayed intensification. Other aims of this study include investigating whether treating both males and females with the same duration of chemotherapy maintains outcomes for males who have previously been treated for an additional year compared to girls, as well as to evaluate the best ways to help patients adhere to oral chemotherapy regimens. Finally, this study will be the first to track the outcomes of subjects with disseminated B-cell Lymphoblastic Leukemia (B-LLy) or Mixed Phenotype Acute Leukemia (MPAL) when treated with B-ALL chemotherapy.
Recruiting2 awards Phase 3
More about Michael Burke, MD
Clinical Trial Related2 years of experience running clinical trials · Led 14 trials as a Principal Investigator · 7 Active Clinical TrialsTreatments Michael Burke, MD has experience with
- Dexamethasone
- Cytarabine
- Blinatumomab
- Cyclophosphamide
- Daunorubicin Hydrochloride
- Pegaspargase
Breakdown of trials Michael Burke, MD has run
Leukemia
Burkitt Lymphoma
Acute Lymphoblastic Leukemia
Acute Myeloid Leukemia
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Michael Burke, MD specialize in?
Michael Burke, MD focuses on Leukemia and Burkitt Lymphoma. In particular, much of their work with Leukemia has involved BCR-ABL1 fusion positive patients, or patients who are ABL-class fusion positive.
Is Michael Burke, MD currently recruiting for clinical trials?
Yes, Michael Burke, MD is currently recruiting for 7 clinical trials in Milwaukee Wisconsin. If you're interested in participating, you should apply.
Are there any treatments that Michael Burke, MD has studied deeply?
Yes, Michael Burke, MD has studied treatments such as Dexamethasone, Cytarabine, Blinatumomab.
What is the best way to schedule an appointment with Michael Burke, MD?
Apply for one of the trials that Michael Burke, MD is conducting.
What is the office address of Michael Burke, MD?
The office of Michael Burke, MD is located at: Children's Hospital of Wisconsin, Milwaukee, Wisconsin 53226 United States. This is the address for their practice at the Children's Hospital of Wisconsin.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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