Dr. Melissa Pugliano-Mauro, MD

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St. Margaret Hospital Dermatology

Studies Breast Cancer
Studies Squamous Cell Carcinoma
1 reported clinical trial
2 drugs studied

Affiliated Hospitals

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St. Margaret Hospital Dermatology

Clinical Trials Melissa Pugliano-Mauro, MD is currently running

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5-Fluorouracil + Imiquimod

for Skin Cancer

This clinical trial proposes to evaluate a relatively unexplored approach to treatment of squamous cell carcinoma (SCC) on the lower extremities. The strategy is to directly and specifically deliver drug to the tumor. For the proposed phase I clinical trial, the investigators will perform intralesional injections of a well characterized, potent chemotherapeutic agent 5-fluorouracil (5FU) with and without a topical application of 0.005% calcipotriene cream to kill topically accessible SCC cells. The goal of the study is to evaluate the safety profile and tolerability of intralesional-5FU with and without a concomitant topical calcipotriene and measure the clinical objective response rate (ORR) in treated lesions compared to untreated lesions 3 weeks after treatment.
Recruiting3 awards Phase 1

More about Melissa Pugliano-Mauro, MD

Clinical Trial Related7 years of experience running clinical trials · Led 1 trial as a Principal Investigator · 1 Active Clinical Trial
Treatments Melissa Pugliano-Mauro, MD has experience with
  • 5-fluorouracil
  • Imiquimod 5% Cream
Breakdown of trials Melissa Pugliano-Mauro, MD has run
Breast Cancer
Squamous Cell Carcinoma

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