Dr. Marlana Orloff, MD
Claim this profileThomas Jefferson University
Studies Melanoma
Studies Uveal Melanoma
10 reported clinical trials
19 drugs studied
Area of expertise
1Melanoma
Stage IV
HLA-A negative
GNAQ positive
2Uveal Melanoma
Stage IV
HLA-A negative
GNAQ positive
Affiliated Hospitals
Clinical Trials Marlana Orloff, MD is currently running
Darovasertib + Crizotinib
for Uveal Melanoma
This trial is testing a new drug combination (IDE196 and crizotinib) on patients with a specific type of eye cancer that has spread. The goal is to see if this combination can stop or slow down the cancer better than other treatments. Crizotinib has been used in treating various cancers with ALK gene rearrangements, showing high response rates.
Recruiting1 award Phase 2 & 38 criteria
APG-115 + Pembrolizumab
for Skin Cancer
This study aims to assess the safety, tolerability, pharmacokinetics, and preliminary efficacy of APG-115, an MDM2 inhibitor, either alone or in combination with pembrolizumab, a programmed cell death protein-1 (PD-1) inhibitor, in patients with metastatic melanomas or advanced solid tumors. Our hypothesis is that restoration of the immune response concomitant to inhibition of the MDM2 pathway (which restores p53 functions) may promote cancer cell death, leading to effective anticancer therapy.
Recruiting1 award Phase 1 & 213 criteria
More about Marlana Orloff, MD
Clinical Trial Related1 year of experience running clinical trials · Led 10 trials as a Principal Investigator · 5 Active Clinical TrialsTreatments Marlana Orloff, MD has experience with
- Pembrolizumab
- IDE196
- Crizotinib
- Ipilimumab
- Nivolumab
- SD-101
Breakdown of trials Marlana Orloff, MD has run
Melanoma
Uveal Melanoma
Eye Cancer
Skin Cancer
Non-Small Cell Lung Cancer
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