Dr. Mark J. Fesler
Claim this profileSaint Luke's Hospital
Studies Lymphoma
Studies Mantle Cell Lymphoma
12 reported clinical trials
32 drugs studied
Area of expertise
1Lymphoma
BCL6 positive
MYC positive
BCL2 positive
2Mantle Cell Lymphoma
CCND1 positive
t(11;14) positive
Stage I
Affiliated Hospitals
Clinical Trials Mark J. Fesler is currently running
Zanubrutinib
for Mantle Cell Lymphoma
This phase III trial tests whether continuous or intermittent zanubrutinib after achieving a complete remission (CR) with rituximab works in older adult patients with mantle cell lymphoma (MCL) who have not received treatment in the past (previously untreated). Rituximab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Zanubrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. When zanubrutinib is used in MCL, the current standard of care is to continue administering the drug indefinitely until disease progression. This continuous treatment comes with clinical as well as financial toxicity, which could be especially detrimental in older patients. For patients who achieve a CR after initial zanubrutinib plus rituximab therapy, it may be safe and equally effective to stop treatment and restart zanubrutinib upon disease progression rather than continuing indefinitely in previously untreated older adult patients with MCL.
Recruiting2 awards Phase 310 criteria
Lenalidomide + Dexamethasone +/- Daratumumab
for Multiple Myeloma
This phase III trial studies how well lenalidomide and dexamethasone works with or without daratumumab in treating patients with high-risk smoldering myeloma. Drugs used in chemotherapy, such as lenalidomide and dexamethasone, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as daratumumab, may induce changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread. Giving lenalidomide and dexamethasone with daratumumab may work better in treating patients with smoldering myeloma.
Recruiting2 awards Phase 312 criteria
More about Mark J. Fesler
Clinical Trial Related8 years of experience running clinical trials · Led 12 trials as a Principal Investigator · 4 Active Clinical TrialsTreatments Mark J. Fesler has experience with
- Rituximab
- Cyclophosphamide
- Dexamethasone
- Autologous Hematopoietic Stem Cell Transplantation
- Prednisone
- Vincristine Sulfate
Breakdown of trials Mark J. Fesler has run
Lymphoma
Mantle Cell Lymphoma
Multiple Myeloma
Large B-Cell Lymphoma
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Mark J. Fesler specialize in?
Mark J. Fesler focuses on Lymphoma and Mantle Cell Lymphoma. In particular, much of their work with Lymphoma has involved BCL6 positive patients, or patients who are MYC positive.
Is Mark J. Fesler currently recruiting for clinical trials?
Yes, Mark J. Fesler is currently recruiting for 4 clinical trials in Chesterfield Missouri. If you're interested in participating, you should apply.
Are there any treatments that Mark J. Fesler has studied deeply?
Yes, Mark J. Fesler has studied treatments such as Rituximab, Cyclophosphamide, Dexamethasone.
What is the best way to schedule an appointment with Mark J. Fesler?
Apply for one of the trials that Mark J. Fesler is conducting.
What is the office address of Mark J. Fesler?
The office of Mark J. Fesler is located at: Saint Luke's Hospital, Chesterfield, Missouri 63017 United States. This is the address for their practice at the Saint Luke's Hospital.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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