Dr. Mark I Boulos, MD, MSc
Claim this profileSunnybrook Health Sciences Centre
Studies Obstructive Sleep Apnea Syndrome
Studies Obstructive Sleep Apnea
5 reported clinical trials
8 drugs studied
Affiliated Hospitals
Clinical Trials Mark I Boulos, MD, MSc is currently running
Genetic Testing
for Stroke Treatment
Stroke is an important cause of death, disability, and memory problems in adults. The build-up of plaque in arteries inside the brain is known as "intracranial atherosclerotic disease" or "ICAD" for short, and can reduce blood flow in the brain. Clopidogrel is a medicine used to prevent strokes because it stops blood from clotting. However, there are some people who do not get as much benefit from Clopidogrel because of differences in their genes; they have a variation in a certain gene and their body is not able to properly process Clopidogrel. Another medication called Ticagrelor can benefit people who have this genetic variation. The study investigators will randomize patients who have had a stroke due to ICAD to receive genetic testing, or standard of care. The standard-of-care group will take Clopidogrel for 90 days. The genetic testing group will complete a genetic test to see if they can properly process Clopidogrel. Depending on the results of the genetic test, patients will either take Clopidogrel or Ticagrelor for 90 days. All patients will have a brain scan at baseline and 90 days to see if they had any new strokes. Patients will also complete tests and questionnaires about function and memory at baseline and 90 days. This study will be one of the first to see if it is feasible and safe to use genetic testing to help choose medications for patients who have had a stroke. This will help the study investigators design a larger study that can test if genetic testing in stroke patients reduces future stroke risk and improves health outcomes.
Recruiting1 award N/A4 criteria
Oropharyngeal Exercises
for Obstructive Sleep Apnea
The goal of this study is to determine whether a randomized controlled trial using oropharyngeal exercises to treat sleep apnea is feasible. Continuous positive airway pressure (CPAP) is the standard therapy for Obstructive sleep apnea (OSA), but it is poorly tolerated by many patients. Oropharyngeal exercises (OPEs) which are commonly used by speech-language pathologists to improve oro-motor strength, may serve as a promising alternative approach. The main questions this study aims to answer are: * Is it feasible to use an oropharyngeal exercise protocol in patients with sleep apnea? * Will oropharyngeal exercises improve sleep apnea severity, daytime sleepiness, sleep quality, mood, workplace performance, and quality of life Participants will be randomized into a supervised OPE intervention arm vs. unsupervised OPE intervention arm vs. sham treatment for a 10-week/5-day per week/two 20-minute session exercise protocol. The exercises will be administered via an app and the investigators will assess feasibility, as well as several sleep-related and oro-motor physiological outcomes before treatment, immediately post-treatment, and 4 weeks post-treatment. The investigators will use the results of this feasibility trial to inform the sample size needed for a larger clinical trial that will determine the efficacy of using oropharyngeal exercises to treat OSA.
Recruiting0 awards N/A3 criteria
More about Mark I Boulos, MD, MSc
Clinical Trial Related1 year of experience running clinical trials · Led 5 trials as a Principal Investigator · 4 Active Clinical TrialsTreatments Mark I Boulos, MD, MSc has experience with
- Home Sleep Apnea Test
- In-laboratory Polysomnography
- Oropharyngeal Exercises
- Sham Exercises
- Clopidogrel
- Ticagrelor
Breakdown of trials Mark I Boulos, MD, MSc has run
Obstructive Sleep Apnea Syndrome
Obstructive Sleep Apnea
Lewy Body Dementia
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Mark I Boulos, MD, MSc specialize in?
Mark I Boulos, MD, MSc focuses on Obstructive Sleep Apnea Syndrome and Obstructive Sleep Apnea. In particular, much of their work with Obstructive Sleep Apnea Syndrome has involved treating patients, or patients who are undergoing treatment.
Is Mark I Boulos, MD, MSc currently recruiting for clinical trials?
Yes, Mark I Boulos, MD, MSc is currently recruiting for 4 clinical trials in Toronto Ontario. If you're interested in participating, you should apply.
Are there any treatments that Mark I Boulos, MD, MSc has studied deeply?
Yes, Mark I Boulos, MD, MSc has studied treatments such as Home Sleep Apnea Test, In-laboratory polysomnography, Oropharyngeal Exercises.
What is the best way to schedule an appointment with Mark I Boulos, MD, MSc?
Apply for one of the trials that Mark I Boulos, MD, MSc is conducting.
What is the office address of Mark I Boulos, MD, MSc?
The office of Mark I Boulos, MD, MSc is located at: Sunnybrook Health Sciences Centre, Toronto, Ontario M4N3M5 Canada. This is the address for their practice at the Sunnybrook Health Sciences Centre.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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