Manish A Shah, M.D. | Patient Care

Dr. Manish Shah, MD

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Weill Cornell Medical College

Studies Stomach Cancer
Studies Esophageal Adenocarcinoma
14 reported clinical trials
29 drugs studied

Area of expertise

1

Stomach Cancer

Manish Shah, MD has run 4 trials for Stomach Cancer. Some of their research focus areas include:

dMMR positive
Stage IV
MSI-H positive
2

Esophageal Adenocarcinoma

Manish Shah, MD has run 4 trials for Esophageal Adenocarcinoma. Some of their research focus areas include:

Stage IV
HER2 positive
HER2 negative

Affiliated Hospitals

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Weill Cornell Medical College

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NYP/Weill Cornell Medical Center

Clinical Trials Manish Shah, MD is currently running

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Chemotherapy + Immunotherapy

for Esophageal and Gastric Cancer

This phase III trial compares the effect of modified fluorouracil, leucovorin calcium, oxaliplatin, and irinotecan (mFOLFIRINOX) to modified fluorouracil, leucovorin calcium, and oxaliplatin (mFOLFOX) for the treatment of advanced, unresectable, or metastatic HER2 negative esophageal, gastroesophageal junction, and gastric adenocarcinoma. The usual approach for patients is treatment with FOLFOX chemotherapy. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Fluorouracil stops cells from making DNA and it may kill tumor cells. Leucovorin is used with fluorouracil to enhance the effects of the drug. Oxaliplatin works by killing, stopping, or slowing the growth of tumor cells. Some patients also receive an immunotherapy drug, nivolumab, in addition to FOLFOX chemotherapy. Immunotherapy may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. Irinotecan blocks certain enzymes needed for cell division and DNA repair, and it may kill tumor cells. Adding irinotecan to the FOLFOX regimen could shrink the cancer and extend the life of patients with advanced gastroesophageal cancers.

Recruiting

2 awards

Phase 3

2 criteria

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Targeted Therapy

for Colorectal Cancer

This research study is comparing two standard of care treatment options based on blood test results for participants who have metastatic colon cancer. The names of the potential treatments involved in this study are: * Active surveillance * FOLFIRI treatment * Nivolumab treatment * Encorafenib/Binimetinib/Cetuximab treatment * Trastuzumab + Pertuzumab

Recruiting

4 awards

Phase 3

15 criteria

More about Manish Shah, MD

Clinical Trial Related

2 years of experience running clinical trials · Led 14 trials as a Principal Investigator · 5 Active Clinical Trials

Treatments Manish Shah, MD has experience with

  • Nivolumab
  • Pembrolizumab
  • Telomelysin (OBP-301)
  • ATP128
  • BI 754091
  • VSV-GP128

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