Dr. Locke J. Bryan
Claim this profileAugusta University Medical Center
Studies Lymphoma
Studies Follicular Lymphoma
9 reported clinical trials
20 drugs studied
Area of expertise
1Lymphoma
Stage III
Stage IV
MYC positive
2Follicular Lymphoma
MYC positive
BCL2 positive
BCL6 positive
Affiliated Hospitals
Clinical Trials Locke J. Bryan is currently running
Rituximab vs Mosunetuzumab
for Follicular Lymphoma
This phase III trial compares the effectiveness of rituximab to mosunetuzumab in treating patients with follicular lymphoma with a low tumor burden. Rituximab is a monoclonal antibody. It binds to a protein called CD20, which is found on B cells (a type of white blood cell) and some types of cancer cells. This may help the immune system kill cancer cells. Mosunetuzumab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. It is not yet known if giving rituximab or mosunetuzumab works better in treating patients with follicular lymphoma with a low tumor burden.
Recruiting2 awards Phase 313 criteria
Zanubrutinib
for Mantle Cell Lymphoma
This phase III trial tests whether continuous or intermittent zanubrutinib after achieving a complete remission (CR) with rituximab works in older adult patients with mantle cell lymphoma (MCL) who have not received treatment in the past (previously untreated). Rituximab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Zanubrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. When zanubrutinib is used in MCL, the current standard of care is to continue administering the drug indefinitely until disease progression. This continuous treatment comes with clinical as well as financial toxicity, which could be especially detrimental in older patients. For patients who achieve a CR after initial zanubrutinib plus rituximab therapy, it may be safe and equally effective to stop treatment and restart zanubrutinib upon disease progression rather than continuing indefinitely in previously untreated older adult patients with MCL.
Recruiting2 awards Phase 310 criteria
More about Locke J. Bryan
Clinical Trial Related6 years of experience running clinical trials · Led 9 trials as a Principal Investigator · 3 Active Clinical TrialsTreatments Locke J. Bryan has experience with
- Rituximab
- Ibrutinib
- Autologous Hematopoietic Stem Cell Transplantation
- IMPT-314
- L-Bcl-2 Antisense Oligonucleotide
- Venetoclax
Breakdown of trials Locke J. Bryan has run
Lymphoma
Follicular Lymphoma
Non-Hodgkin's Lymphoma
Mantle Cell Lymphoma
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Locke J. Bryan specialize in?
Locke J. Bryan focuses on Lymphoma and Follicular Lymphoma. In particular, much of their work with Lymphoma has involved Stage III patients, or patients who are Stage IV.
Is Locke J. Bryan currently recruiting for clinical trials?
Yes, Locke J. Bryan is currently recruiting for 3 clinical trials in Augusta Georgia. If you're interested in participating, you should apply.
Are there any treatments that Locke J. Bryan has studied deeply?
Yes, Locke J. Bryan has studied treatments such as Rituximab, Ibrutinib, Autologous Hematopoietic Stem Cell Transplantation.
What is the best way to schedule an appointment with Locke J. Bryan?
Apply for one of the trials that Locke J. Bryan is conducting.
What is the office address of Locke J. Bryan?
The office of Locke J. Bryan is located at: Augusta University Medical Center, Augusta, Georgia 30912 United States. This is the address for their practice at the Augusta University Medical Center.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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