Dr. Lindsey Fitzgerald

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Huntsman Cancer Institute/University of Utah

Studies Lymphoma
Studies Chronic Lymphocytic Leukemia
4 reported clinical trials
11 drugs studied

Area of expertise

1

Lymphoma

Lindsey Fitzgerald has run 3 trials for Lymphoma. Some of their research focus areas include:

MYC positive
BCL2 positive
BCL6 positive
2

Chronic Lymphocytic Leukemia

Lindsey Fitzgerald has run 2 trials for Chronic Lymphocytic Leukemia. Some of their research focus areas include:

13q positive
13q negative
12 positive

Affiliated Hospitals

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Huntsman Cancer Institute/University Of Utah

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George E. Wahlen Department Of Veterans Affairs Medical Center

Clinical Trials Lindsey Fitzgerald is currently running

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Nicotinamide

for Chronic Lymphocytic Leukemia and Skin Cancer

This is a randomized, phase II, double-blind, placebo-controlled trial with planned crossover to the intervention arm after 1 year. Consenting patients with CLL who have had at least one NMSC diagnosed in the past year will be randomized to receive either oral nicotinamide 500 mg twice daily (BID) for 1 year or oral placebo 1 tablet twice daily for 1 year. Patients will be stratified according to CLL therapy and the number of prior NMSC. At the end of 1 year, patients will undergo dermatologic examination and the number of new NMSC will be quantified. The number of patients who develop new NMSC in each arm will be documented. At this time, patients will be unblinded and all patients will receive Nicotinamide 500 mg BID for an additional year. At the end of this second year, patients will again undergo dermatologic examination, and the number of new NMSC will be quantified. The number of patients who develop NMSC will be documented. Skin biopsies will be taken for correlative studies. Enrollment will be split into two parts separated by an interim analysis. Part 1 will accrue 40 patients: 20 to each arm. After 40 patients have completed their 12 month visit an interim futility analysis will be conducted prior to recruiting more patients. The study will stop if the difference in the number of patients with NMSC between control and treatment arms is 0 or less (i.e., absolutely no evidence that the treatment is better than control). If the trial is not stopped, the investigators will proceed with Part 2 and recruit 46 more patients.

Recruiting

0 awards

Phase 2

8 criteria

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Venetoclax + Obinutuzumab

for Leukemia

This phase III trial compares early treatment with venetoclax and obinutuzumab versus delayed treatment with venetoclax and obinutuzumab in patients with newly diagnosed high-risk chronic lymphocytic leukemia or small lymphocytic lymphoma. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Immunotherapy with monoclonal antibodies, such as obinutuzumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Starting treatment with the venetoclax and obinutuzumab early (before patients have symptoms) may have better outcomes for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma compared to starting treatment with the venetoclax and obinutuzumab after patients show symptoms.

Recruiting

2 awards

Phase 3

1 criteria

More about Lindsey Fitzgerald

Clinical Trial Related

3 years of experience running clinical trials · Led 4 trials as a Principal Investigator · 3 Active Clinical Trials

Treatments Lindsey Fitzgerald has experience with

  • Nicotinamide
  • Placebo
  • Cyclophosphamide
  • Oral Azacitidine
  • Prednisone
  • Rituximab

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