Dr. LaQuisa HIll, MD

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Baylor College of Medicine

Studies Acute Lymphoblastic Leukemia
Studies Acute Myelogenous Leukemia
5 reported clinical trials
7 drugs studied

Affiliated Hospitals

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Baylor College Of Medicine
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Houston Methodist Hospital

Clinical Trials LaQuisa HIll, MD is currently running

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MB-105

for T-cell Lymphoma

This is a single arm, two-stage, Phase 2, open-label, multicenter study of MB-105 in patients with CD5 Positive (CD5+) Relapsed / Refractory T-cell Lymphoma (r/r TCL). This study will apply a Simon two-stage optimal design.
Recruiting1 award Phase 26 criteria
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CAR T-Cell Therapy

for Blood Cancer

Patients eligible for this study have a type of blood cancer called T-cell leukemia or lymphoma (lymph gland cancer). The body has different ways of fighting infection and disease. This study combines two different ways of fighting disease with antibodies and T cells. Antibodies are types of proteins that protect the body from bacterial and other diseases. T cells, or T lymphocytes, are special infection-fighting blood cells that can kill other cells including tumor cells. Both antibodies and T cells have been used to treat cancer; they have shown promise, but have not been strong enough to cure most patients. T cells can kill tumor cells but there normally are not enough of them to kill all the tumor cells. Some researchers have taken T cells from a person's blood, grown more of them in the laboratory and then given them back to the person. The antibody used in this study is called anti-CD7. This antibody sticks to T-cell leukemia or lymphoma cells because of a substance on the outside of these cells called CD7. CD7 antibodies have been used to treat people with T-cell leukemia and lymphoma. For this study, anti-CD7 has been changed so that instead of floating free in the blood it is now joined to the T cells. When an antibody is joined to a T cell in this way it is called a chimeric receptor. In the laboratory, investigators have also found that T cells work better if they also add proteins that stimulate T cells, such as one called CD28. Adding the CD28 makes the cells grow better and last longer in the body, thus giving the cells a better chance of killing the leukemia or lymphoma cells. In this study, investigators attach the CD7 chimeric receptor with CD28 added to it to T cells. Investigators will then test how long the cells last. These CD7 chimeric receptor T cells with CD28 are investigational products not approved by the Food and Drug Administration.
Recruiting1 award Phase 1

More about LaQuisa HIll, MD

Clinical Trial Related1 year of experience running clinical trials · Led 5 trials as a Principal Investigator · 2 Active Clinical Trials
Treatments LaQuisa HIll, MD has experience with
  • CD7.CAR/28zeta CAR T Cells
  • Cyclophosphamide
  • Fludarabine
  • Donor Search Prognosis Score
  • MB-105
  • CLL-1.CAR T Cells

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