Kristina Simonyan, MD, PhD, Dr med ...

Dr. Kristina Simonyan, MD, PhD

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Massachusetts Eye and Ear Infirmary

Studies Dysphonia
Studies Spasmodic Dysphonia
7 reported clinical trials
9 drugs studied

Affiliated Hospitals

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Massachusetts Eye And Ear Infirmary
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Massachusetts Eye And Ear And University Of California San Francisco

Clinical Trials Kristina Simonyan, MD, PhD is currently running

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Sensory Block + Brain Imaging

for Spasmodic Dysphonia

The researchers will examine functional neural correlates that differentiate between laryngeal dystonia and voice tremor and contribute to disorder-specific pathophysiology using a cross-disciplinary approach of multimodal brain imaging.
Recruiting2 awards Phase < 17 criteria
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Imaging Genetics

for Spasmodic Dysphonia

The contribution of genetic risk factors to the development of focal dystonias is evident. However, understanding of how variations in the causative gene expression lead to variations in brain abnormalities in different phenotypes of dystonia (e.g., familial, sporadic) remains limited. The research program of the investigators is set to determine the relationship between brain changes and genetic risk factors in laryngeal dystonia (or spasmodic dysphonia). The researchers use a novel approach of combined imaging genetics, next-generation DNA sequencing, and clinical-behavioral testing. The use of a cross-disciplinary approach as a tool for the discovery of the mediating neural mechanisms that bridge the gap from DNA sequence to the pathophysiology of dystonia holds a promise for the understanding of the mechanistic aspects of brain function affected by risk gene variants, which can be used reliably for the discovery of associated genes and neural integrity markers for this disorder. The expected outcome of this study may lead to better clinical management of this disorder, including its improved detection, accurate diagnosis, and assessment of the risk of developing dystonia in family members.
Recruiting1 award N/A10 criteria

More about Kristina Simonyan, MD, PhD

Clinical Trial Related3 years of experience running clinical trials · Led 7 trials as a Principal Investigator · 6 Active Clinical Trials
Treatments Kristina Simonyan, MD, PhD has experience with
  • Neurofeedback Brain-Computer Interface
  • DystoniaNet
  • Blood Draw
  • MRI
  • Sodium Oxybate
  • Brain Imaging

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