Dr. Jonathan Roberts, MD - Bleeding ...

Dr. Jonathan C Roberts, MD

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Bleeding and Clotting Disorders Institute

Studies Von Willebrand Disease
Studies Hemophilia
9 reported clinical trials
10 drugs studied

Area of expertise

1Von Willebrand Disease
Jonathan C Roberts, MD has run 4 trials for Von Willebrand Disease. Some of their research focus areas include:
VWF collagen binding positive
VWF activity positive
VWF antigen positive
2Hemophilia
Jonathan C Roberts, MD has run 2 trials for Hemophilia. Some of their research focus areas include:
VWF collagen binding positive
VWF activity positive
VWF antigen positive

Affiliated Hospitals

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Bleeding And Clotting Disorders Institute
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Memorial Regional Hospital

Clinical Trials Jonathan C Roberts, MD is currently running

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Natural History Study

for Blood Disorders

In parallel with the growth of American Thrombosis and Hemostasis Network's (ATHN) clinical studies, the number of new therapies for all congenital and acquired hematologic conditions, not just those for bleeding and clotting disorders, is increasing significantly. Some of the recently FDA-approved therapies for congenital and acquired hematologic conditions have yet to demonstrate long-term safety and effectiveness beyond the pivotal trials that led to their approval. In addition, results from well-controlled, pivotal studies often cannot be replicated once a therapy has been approved for general use.(1,2,3,4) In 2019 alone, the United States Food and Drug Administration (FDA) has issued approvals for twenty-four new therapies for congenital and acquired hematologic conditions.(5) In addition, almost 10,000 new studies for hematologic diseases are currently registered on www.clinicaltrials.gov.(6) With this increase in potential new therapies on the horizon, it is imperative that clinicians and clinical researchers in the field of non-neoplastic hematology have a uniform, secure, unbiased, and enduring method to collect long-term safety and efficacy data. ATHN Transcends is a cohort study to determine the safety, effectiveness, and practice of therapies used in the treatment of participants with congenital or acquired non-neoplastic blood disorders and connective tissue disorders with bleeding tendency. The study consists of 7 cohorts with additional study "arms" and "modules" branching off from the cohorts. The overarching objective of this longitudinal, observational study is to characterize the safety, effectiveness and practice of treatments for all people with congenital and acquired hematologic disorders in the US. As emphasized in a recently published review, accurate, uniform and quality national data collection is critical in clinical research, particularly for longitudinal cohort studies covering a lifetime of biologic risk.(7)
Recruiting1 award N/A1 criteria
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VWF Replacement Therapy

for Von Willebrand Disease

In pregnant women with von Willebrand disease (VWD) who by the third trimester do not have von Willebrand factor (VWF) or factor VIII (FVIII) levels greater than 50-100%, specific guidance is lacking for delivery planning in terms of how high of a VWF level should be achieved to reduce bleeding. This is a prospective, open-label, cohort study in women with VWD using Wilate VWF replacement therapy to maintain trough or minimum VWF levels of 100-150% for delivery and the immediate postpartum period, followed by levels of 50-100% for 5-10 days after delivery, depending upon the route of delivery. The primary objective is to document the rate of primary postpartum hemorrhage (PPH). The secondary objective is to document further effectiveness outcomes and safety.
Recruiting2 awards N/A3 criteria

More about Jonathan C Roberts, MD

Clinical Trial Related3 years of experience running clinical trials · Led 9 trials as a Principal Investigator · 5 Active Clinical Trials
Treatments Jonathan C Roberts, MD has experience with
  • Emicizumab
  • Wilate
  • Placebo
  • CLBS16
  • Antihemophilic Factor (Recombinant)
  • Von Willebrand Factor (Recombinant)

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