Dr. Ingrid A Mayer, MD
Claim this profileVanderbilt University/Ingram Cancer Center
Studies Breast Cancer
Studies Breast cancer
10 reported clinical trials
30 drugs studied
Area of expertise
1Breast Cancer
Stage IV
HER2 negative
ER positive
2Breast Cancer
Stage IV
HER2 negative
ER positive
Affiliated Hospitals
Clinical Trials Ingrid A Mayer, MD is currently running
Avelumab Combinations
for Triple Negative Breast Cancer
This phase II trial studies how well the combination of avelumab with liposomal doxorubicin with or without binimetinib, or the combination of avelumab with sacituzumab govitecan works in treating patients with triple negative breast cancer that is stage IV or is not able to be removed by surgery (unresectable) and has come back (recurrent). Immunotherapy with checkpoint inhibitors like avelumab require activation of the patient's immune system. This trial includes a two week induction or lead-in of medications that can stimulate the immune system. It is our hope that this induction will improve the response to immunotherapy with avelumab. One treatment, sacituzumab Govitecan, is a monoclonal antibody called sacituzumab linked to a chemotherapy drug called SN-38. Sacituzumab govitecan is a form of targeted therapy because it attaches to specific molecules (receptors) on the surface of tumor cells, known as Tumor-associated calcium signal transducer 2 (TROP2) receptors, and delivers SN-38 to kill them. Another treatment, liposomal doxorubicin, is a form of the anticancer drug doxorubicin that is contained in very tiny, fat-like particles. It may have fewer side effects and work better than doxorubicin, and may enhance factors associated with immune response. The third medication is called binimetinib, which may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth, and may help activate the immune system. It is not yet known whether giving avelumab in combination with liposomal doxorubicin with or without binimetinib, or the combination of avelumab with sacituzumab govitecan will work better in treating patients with triple negative breast cancer.
Recruiting1 award Phase 211 criteria
Personalized Adaptive Novel Agents
for Breast Cancer
This trial is testing new medicines along with regular cancer treatment to find the best combinations for breast cancer patients. It focuses on identifying which treatments work best based on specific cancer characteristics. Early signs of success are monitored using MRI scans and tests on blood and tissue samples.
Recruiting1 award Phase 216 criteria
More about Ingrid A Mayer, MD
Clinical Trial Related4 years of experience running clinical trials · Led 10 trials as a Principal Investigator · 2 Active Clinical TrialsTreatments Ingrid A Mayer, MD has experience with
- Palbociclib
- Sacituzumab Govitecan
- Avelumab
- BYL719
- Letrozole
- Ribociclib
Breakdown of trials Ingrid A Mayer, MD has run
Breast Cancer
Breast cancer
Parotid Gland Cancer
Cancer
Tumors
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