Imran Zoberi, MD | Department of ...

Dr. Imran Zoberi, M.D.

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Washington University School of Medicine

Studies Breast Cancer
Studies Skin Cancer
8 reported clinical trials
13 drugs studied

Area of expertise

1Breast Cancer
Imran Zoberi, M.D. has run 6 trials for Breast Cancer. Some of their research focus areas include:
Stage I
ER positive
PR positive
2Skin Cancer
Imran Zoberi, M.D. has run 2 trials for Skin Cancer.

Affiliated Hospitals

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Washington University School Of Medicine
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Washington University St. Louis

Clinical Trials Imran Zoberi, M.D. is currently running

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Circulating Tumor DNA

for Cancer

Earlier detection of disease recurrence will enable greater treatment options and has strong potential to improve patient outcomes. This project is translational and has the potential to lead to future translational research opportunities, including interventional trials in which therapeutic escalation is offered at the early circulating tumor DNA (ctDNA) molecular residual disease (MRD) detection timepoint. Ultimately, the integration of ctDNA into the clinical workflow has the potential to enhance cancer diagnosis, treatment, surveillance, and prognosis, and guide clinical decision-making in this era of personalized precision medicine.
Recruiting1 award N/A1 criteria
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Ultra-Hypofractionated vs. Hypofractionated Radiation

for Breast Cancer

In breast cancer patients with nodal involvement, numerous studies have demonstrated that adjuvant radiation therapy reduces the risk of local recurrence, regional recurrence, and distant metastases, in addition to improving survival. The dose and fractionation for adjuvant breast radiation therapy has evolved over time, as novel schedules have been compared to the current standard of care. Hypofractionated radiation therapy (266 cGy per fraction x 15-16 fractions over 3 weeks) has been shown to result in equivalent oncologic outcomes, as well as equivalent acute and late toxicity, when compared to standard fractionation (200 cGy per fraction x 25 fractions over 5 weeks). Subsequently, hypofractionated breast radiation has become the current standard of care. More recently, ultra-hypofractionated breast radiation (520 cGy per fraction x 5 fractions over 1 week) was shown in a randomized trial to be non-inferior to hypofractionated radiation when treating the breast after lumpectomy. However, the efficacy and toxicity of using ultra-hypofractionated radiation therapy when also treating the regional nodes has not been reported. This is important, as there is greater radiation exposure to several normal tissues, such as the arm/shoulder, brachial plexus, normal lymphatics, heart, and lung, when treating the regional nodes. In this randomized study, the investigators aim to compare the tolerability and efficacy of ultra-hypofractionated breast/chest wall and regional nodal radiation (SWIFT RT) against hypofractionated radiation (RT). The investigators will evaluate acute and late toxicity, oncologic outcomes (including local recurrence, regional recurrence, distant metastasis, and overall survival), cosmesis, and patient-reported quality of life. The investigators will collect blood samples for correlative studies of biomarkers of fibrosis and cardiac toxicity.
Recruiting1 award Phase 29 criteria

More about Imran Zoberi, M.D.

Clinical Trial Related3 years of experience running clinical trials · Led 8 trials as a Principal Investigator · 4 Active Clinical Trials
Treatments Imran Zoberi, M.D. has experience with
  • Radiation Therapy
  • Three Fraction APBI
  • Accelerated Partial Breast Irradiation
  • Photon
  • Proton
  • Circulating Tumor DNA (ctDNA)

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