Dr. Hussein Assi
Claim this profileBoston Medical Center
Studies Gastric Cancer
Studies Uterine Tumors
6 reported clinical trials
14 drugs studied
Area of expertise
1Gastric Cancer
Stage IV
Stage III
HER2 negative
2Uterine Tumors
Stage IV
HER2 negative
KRAS positive
Affiliated Hospitals
Clinical Trials Hussein Assi is currently running
Chemotherapy + Immunotherapy
for Esophageal and Gastric Cancer
This phase III trial compares the effect of modified fluorouracil, leucovorin calcium, oxaliplatin, and irinotecan (mFOLFIRINOX) to modified fluorouracil, leucovorin calcium, and oxaliplatin (mFOLFOX) for the treatment of advanced, unresectable, or metastatic HER2 negative esophageal, gastroesophageal junction, and gastric adenocarcinoma. The usual approach for patients is treatment with FOLFOX chemotherapy. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Fluorouracil stops cells from making DNA and it may kill tumor cells. Leucovorin is used with fluorouracil to enhance the effects of the drug. Oxaliplatin works by killing, stopping, or slowing the growth of tumor cells. Some patients also receive an immunotherapy drug, nivolumab, in addition to FOLFOX chemotherapy. Immunotherapy may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. Irinotecan blocks certain enzymes needed for cell division and DNA repair, and it may kill tumor cells. Adding irinotecan to the FOLFOX regimen could shrink the cancer and extend the life of patients with advanced gastroesophageal cancers.
Recruiting2 awards Phase 32 criteria
RYZ101
for Neuroendocrine Tumors
This trial tests RYZ101, a new drug, in patients with advanced GEP-NETs that haven't responded to previous treatments. The drug aims to target specific receptors on the tumor cells to stop their growth.
Recruiting2 awards Phase 312 criteria
More about Hussein Assi
Clinical Trial Related2 years of experience running clinical trials · Led 6 trials as a Principal Investigator · 3 Active Clinical TrialsTreatments Hussein Assi has experience with
- Nivolumab
- RYZ101
- Carboplatin
- Ipilimumab
- Paclitaxel
- Radiation Therapy
Breakdown of trials Hussein Assi has run
Gastric Cancer
Uterine Tumors
Neuroendocrine Tumors
Pancreatic Neuroendocrine Tumors
Carcinoid Tumor
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