Dr. Donald B. Wender | Nylen Cancer ...

Dr. Donald Wender

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Siouxland Regional Cancer Center

Studies Lung Cancer
Studies Non-Small Cell Lung Cancer
36 reported clinical trials
90 drugs studied

Area of expertise

1

Lung Cancer

Donald Wender has run 7 trials for Lung Cancer. Some of their research focus areas include:

Stage III
Stage II
Stage I
2

Non-Small Cell Lung Cancer

Donald Wender has run 6 trials for Non-Small Cell Lung Cancer. Some of their research focus areas include:

Stage III
Stage II
Stage IV

Affiliated Hospitals

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Siouxland Regional Cancer Center

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June E. Nylen Cancer Center

Clinical Trials Donald Wender is currently running

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Chemotherapy + Immunotherapy

for Esophageal and Gastric Cancer

This phase III trial compares the effect of modified fluorouracil, leucovorin calcium, oxaliplatin, and irinotecan (mFOLFIRINOX) to modified fluorouracil, leucovorin calcium, and oxaliplatin (mFOLFOX) for the treatment of advanced, unresectable, or metastatic HER2 negative esophageal, gastroesophageal junction, and gastric adenocarcinoma. The usual approach for patients is treatment with FOLFOX chemotherapy. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Fluorouracil stops cells from making DNA and it may kill tumor cells. Leucovorin is used with fluorouracil to enhance the effects of the drug. Oxaliplatin works by killing, stopping, or slowing the growth of tumor cells. Some patients also receive an immunotherapy drug, nivolumab, in addition to FOLFOX chemotherapy. Immunotherapy may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. Irinotecan blocks certain enzymes needed for cell division and DNA repair, and it may kill tumor cells. Adding irinotecan to the FOLFOX regimen could shrink the cancer and extend the life of patients with advanced gastroesophageal cancers.

Recruiting

2 awards

Phase 3

2 criteria

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Lomustine + Standard Therapy

for Glioblastoma

This phase III trial compares the effect of adding lomustine to standard chemotherapy with temozolomide and radiation therapy versus temozolomide and radiation therapy alone in shrinking or stabilizing newly diagnosed MGMT methylated glioblastoma. MGMT methylated tumors are more likely to respond to temozolomide chemotherapy. Temozolomide is in a class of medications called alkylating agents. It works by damaging the cell's DNA and may kill tumor cells and slow down or stop tumor growth. Lomustine is a chemotherapy drug and in a class of medications called alkylating agents. It damages the cell's DNA and may kill tumor cells. Radiation therapy uses high energy x-ray photons to kill tumor cells and shrink tumors. Adding lomustine to standard chemotherapy with temozolomide and radiation therapy may shrink or stabilize glioblastoma.

Recruiting

2 awards

Phase 3

4 criteria

More about Donald Wender

Clinical Trial Related

7 years of experience running clinical trials · Led 36 trials as a Principal Investigator · 8 Active Clinical Trials

Treatments Donald Wender has experience with

  • Carboplatin
  • Nivolumab
  • Cisplatin
  • Pembrolizumab
  • Lenalidomide
  • Rituximab

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