Dr. Deborah Doroshow, MD, PhD
Claim this profileMount Sinai Hospital
Studies Cancer
Studies Solid Tumors
17 reported clinical trials
41 drugs studied
Area of expertise
1Cancer
Stage IV
KRAS positive
BRAF positive
2Solid Tumors
Stage IV
Stage III
AKT2 positive
Affiliated Hospitals
Clinical Trials Deborah Doroshow, MD, PhD is currently running
Pembrolizumab
for Advanced Non-Small Cell Lung Cancer
This single center open-label trial will enroll a single cohort of patients with advanced non-small cell lung cancer (NSCLC) who are ineligible for treatment with curative intent due to 1) disease stage IV, or 2) inability to tolerate intensive surgery or chemo-radiation. Patients will be eligible for the trial if ISMMS reviewed samples from tumor biopsy have a PDL-1 TPS ≥ 1% and have ECOG performance status rated 2 or 3. All patients will receive anti PD-1 therapy with pembrolizumab 200mg IV every 3 weeks, during which patients will also undergo serial QOL assessments. This trial will follow a phase II single arm, open label design. The study will enroll 45 patients evaluable for the primary endpoint of which will be change in QOL as measured by the EORTC's QLQ-C30 between Day 1 and Day 84 +/- 7 days. Secondary outcomes including evaluation for development of confounding mental health conditions will be evaluated via serial HADS assessments. Concomitant radiographic assessment with PET/CT, regardless of the doses of pembrolizumab received, will allow for evaluation of secondary efficacy outcomes, including disease response by RECIST 1.1 criteria.
Recruiting1 award Phase 215 criteria
XMT-2056
for Breast Cancer
A Study of XMT-2056 in advanced/recurrent solid tumors that express HER2.
Recruiting1 award Phase 1
More about Deborah Doroshow, MD, PhD
Clinical Trial Related4 years of experience running clinical trials · Led 17 trials as a Principal Investigator · 9 Active Clinical TrialsTreatments Deborah Doroshow, MD, PhD has experience with
- Paclitaxel
- Pembrolizumab
- Atezolizumab
- Ipatasertib
- Binimetinib
- Palbociclib
Breakdown of trials Deborah Doroshow, MD, PhD has run
Cancer
Solid Tumors
Cystic Tumor
Lung Cancer
Ovarian Cancer
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