Dr. David L. Grinblatt, MD | Evanston ...

Dr. David L. Grinblatt

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NorthShore University HealthSystem-Evanston Hospital

Studies Chronic Lymphocytic Leukemia
Studies Lymphoma
6 reported clinical trials
20 drugs studied

Area of expertise

1Chronic Lymphocytic Leukemia
David L. Grinblatt has run 2 trials for Chronic Lymphocytic Leukemia. Some of their research focus areas include:
13q positive
13q negative
12 positive
2Lymphoma
David L. Grinblatt has run 2 trials for Lymphoma. Some of their research focus areas include:
13q positive
13q negative
12 positive

Affiliated Hospitals

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NorthShore University HealthSystem-Evanston Hospital
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NorthShore University HealthSystem-Glenbrook Hospital

Clinical Trials David L. Grinblatt is currently running

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Blinatumomab + Chemotherapy

for Leukemia

This phase III trial compares the effect of usual treatment of chemotherapy and steroids and a tyrosine kinase inhibitor (TKI) to the same treatment plus blinatumomab. Blinatumomab is a Bi-specific T-Cell Engager ('BiTE') that may interfere with the ability of cancer cells to grow and spread. The information gained from this study may help researchers determine if combination therapy with steroids, TKIs, and blinatumomab work better than the standard of care.
Recruiting2 awards Phase 310 criteria
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Novel Therapies

for Acute Myeloid Leukemia

This phase II MyeloMATCH treatment trial tests whether the standard approach of cytarabine and daunorubicin in comparison to the following experimental regimens works to shrink cancer in patients with high risk acute myeloid leukemia (AML): 1) daunorubicin and cytarabine liposome alone; 2) cytarabine and daunorubicin with venetoclax; 3) azacitidine and venetoclax; 4) daunorubicin and cytarabine liposome and venetoclax. "High-risk" refers to traits that have been known to make the AML harder to treat. Cytarabine is in a class of medications called antimetabolites. It works by slowing or stopping the growth of cancer cells in the body. Daunorubicin is in a class of medications called anthracyclines. It also works by slowing or stopping the growth of cancer cells in the body. Azacitidine is in a class of medications called demethylation agents. It works by helping the bone marrow to produce normal blood cells and by killing abnormal cells. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. There is evidence that these newer experimental treatment regimens may work better in getting rid of more AML compared to the standard approach of cytarabine and daunorubicin.
Recruiting1 award Phase 217 criteria

More about David L. Grinblatt

Clinical Trial Related6 years of experience running clinical trials · Led 6 trials as a Principal Investigator · 4 Active Clinical Trials
Treatments David L. Grinblatt has experience with
  • Venetoclax
  • Cytarabine
  • Obinutuzumab
  • Dexamethasone
  • Ibrutinib
  • Daratumumab

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