Dr. David M Biko, MD

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Children's Hospital of Philadelphia

Studies Lung Transplant Rejection
1 reported clinical trial
1 drug studied

Affiliated Hospitals

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Children's Hospital Of Philadelphia

Clinical Trials David M Biko, MD is currently running

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Hyperpolarized Xenon MRI

for Lung Transplant Rejection

This study will use Magnetic Resonance Imaging (MRI) to study the lungs of 90 volunteers using the inhaled contrast agent, hyperpolarized xenon-129. Once inhaled, this gas can provide information to imagers regarding lung functionality across specific regions of the lungs by assessing the replacement of air during the normal breathing cycle, how much oxygen is in the airspaces, and if the natural spongy tissue structure has been compromised by lung disease. Of the 90 subjects, 70 will be patients who received lung transplantation from the Penn/Temple Lung Transplant Teams and are receiving follow up treatment at HUP or TUH, 10 will be healthy control subjects who participated favorably in our HP 129Xe imaging protocol, and 10 will be patients who have been diagnosed with chronic obstructive pulmonary disease (COPD)-preferentially recruited from the Temple University COPDGene cohort, who have never undergone a lung transplant. 20 of the lung transplant recipient subjects will be patients who have received a recent clinical diagnosis of chronic lung allograft dysfunction (CLAD) prior to enrollment in our study, while the other 50 will have recently undergone their initial transplant surgery at the time of enrollment.
Recruiting1 award N/A3 criteria

More about David M Biko, MD

Clinical Trial Related4 years of experience running clinical trials · Led 1 trial as a Principal Investigator · 1 Active Clinical Trial
Treatments David M Biko, MD has experience with
  • Hyperpolarized 129-Xenon (MagniXene) MRI Of The Lung
Breakdown of trials David M Biko, MD has run
Lung Transplant Rejection

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