Dr. Daniel Wang, MD | Houston, TX 77030 ...

Dr. Daniel Y. Wang

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Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Studies Skin Cancer
Studies Lung Cancer
6 reported clinical trials
17 drugs studied

Area of expertise

1Skin Cancer
Daniel Y. Wang has run 2 trials for Skin Cancer. Some of their research focus areas include:
Stage IV
Stage III
BRAF positive
2Lung Cancer
Daniel Y. Wang has run 2 trials for Lung Cancer. Some of their research focus areas include:
Stage IV
HER2 positive
EGFR negative

Affiliated Hospitals

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Baylor College Of Medicine/Dan L Duncan Comprehensive Cancer Center
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Ben Taub General Hospital

Clinical Trials Daniel Y. Wang is currently running

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Oncolytic Virus + CAR T-Cell Therapy

for Solid Cancers

This study is a first in human Phase 1 study that involves patients with a type of cancer called HER2 (Human Epidermal Growth Factor Receptor 2) positive cancer. This study asks patients to volunteer to take part in a research study investigating the safety and efficacy of using special immune cells called HER2 chimeric antigen receptor specific cytotoxic T lymphocytes (HER2 specific CAR T cells), in combination with intra-tumor injection of CAdVEC, an oncolytic adenovirus that is designed to help the immune system including HER2 specific CAR T cell react to the tumor. The study is looking at combining these two treatments together, because we think that the combination of treatments will work better than each treatment alone. We also hope to learn the best dose level of the treatments and whether or not it is safe to use them together. In this study, CAdVEC will be injected into participants tumor at one tumor site which is most easiest to reach. Once it infects the cancer cells, activation of the immune response will occur so it can attack and kill cancer cells. (This approach may have limited effects on the other tumor sites that have not received the oncolytic virus injection, so, patients will also receive specific T cells following the intratumor CAdVEC injection.) These T cells are special infection-fighting blood cells that can kill cells infected with viruses and tumor cells. Investigators want to see if these cells can survive in the blood and affect the tumor. Both CAdVEC and HER2-specific autologous CAR T are investigational products. They are not approved by the FDA.
Recruiting1 award Phase 115 criteria
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VO + Nivolumab

for Advanced Melanoma

This is a randomized, controlled, multicenter, open-label Phase 3 clinical study comparing VO in combination with nivolumab versus Physician's Choice treatment for patients with unresectable Stage IIIb-IV cutaneous melanoma whose disease progressed on an anti PD-1 and an anti-CTLA-4 containing regimen (administered either as a combination regimen or in sequence) or who are not candidates for treatment with an anti-CTLA-4 therapy.
Recruiting2 awards Phase 33 criteria

More about Daniel Y. Wang

Clinical Trial Related3 years of experience running clinical trials · Led 6 trials as a Principal Investigator · 2 Active Clinical Trials
Treatments Daniel Y. Wang has experience with
  • Pembrolizumab
  • Therapeutic Conventional Surgery
  • Avelumab
  • Biopsy
  • Biospecimen Collection
  • Computed Tomography

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