Dr. Christopher R. Foss

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Presbyterian Intercommunity Hospital

Studies Fallopian Tube Cancer
Studies Ovarian Cancer
4 reported clinical trials
22 drugs studied

Area of expertise

1

Fallopian Tube Cancer

Christopher R. Foss has run 2 trials for Fallopian Tube Cancer. Some of their research focus areas include:

Stage IV
Stage III
HRAS positive
2

Ovarian Cancer

Christopher R. Foss has run 2 trials for Ovarian Cancer. Some of their research focus areas include:

Stage IV
Stage III
HRAS positive

Affiliated Hospitals

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Presbyterian Intercommunity Hospital

Clinical Trials Christopher R. Foss is currently running

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Selumetinib + Olaparib

for Ovarian and Endometrial Cancer

This phase II ComboMATCH treatment trial compares selumetinib plus olaparib to selumetinib alone in women with endometrial or ovarian (fallopian tube and primary peritoneal) cancer that has come back (recurrent) or that remains despite treatment (persistent) and harbors a mutation in the RAS pathway. Selumetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Olaparib is an inhibitor of PARP, an enzyme that helps repair deoxyribonucleic acid (DNA) when it becomes damaged. Blocking PARP may help keep tumor cells from repairing their damaged DNA, causing them to die. PARP inhibitors are a type of targeted therapy. The addition of olaparib to selumetinib could increase the percentage of tumors that shrink as well as lengthen the time that the tumors remain stable (without progression) as compared to selumetinib alone.

Recruiting

1 award

Phase 2

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Targeted Therapy

for Solid Tumors

This ComboMATCH patient screening trial is the gateway to a coordinated set of clinical trials to study cancer treatment directed by genetic testing. Patients with solid tumors that have spread to nearby tissue or lymph nodes (locally advanced) or have spread to other places in the body (advanced) and have progressed on at least one line of standard systemic therapy or have no standard treatment that has been shown to prolong overall survival may be candidates for these trials. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with some genetic changes or abnormalities (mutations) may benefit from treatment that targets that particular genetic mutation. ComboMATCH is designed to match patients to a treatment that may work to control their tumor and may help doctors plan better treatment for patients with locally advanced or advanced solid tumors.

Recruiting

1 award

Phase 2

17 criteria

More about Christopher R. Foss

Clinical Trial Related

2 years of experience running clinical trials · Led 4 trials as a Principal Investigator · 2 Active Clinical Trials

Treatments Christopher R. Foss has experience with

  • Binimetinib
  • Fluorouracil
  • Nilotinib Hydrochloride Monohydrate
  • Olaparib
  • Oxaliplatin
  • Paclitaxel

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