Dr. Christopher DeRenzo, MD

Claim this profile
Studies Brain Tumor
Studies Glioblastoma
1 reported clinical trial
1 drug studied

Area of expertise

1

Brain Tumor

Christopher DeRenzo, MD has run 1 trial for Brain Tumor. Some of their research focus areas include:

B7-H3 positive
H3K27 positive
2

Glioblastoma

Christopher DeRenzo, MD has run 1 trial for Glioblastoma. Some of their research focus areas include:

B7-H3 positive
H3K27 positive

Clinical Trials Christopher DeRenzo, MD is currently running

Image of trial facility.

B7-H3-CAR T Cells

for Brain Tumor

Loc3CAR is a Phase I clinical trial evaluating the use of autologous B7-H3-CAR T cells for participants ≤ 21 years old with primary CNS neoplasms. B7-H3-CAR T cells will be locoregionally administered via a CNS reservoir catheter. Study participants will be divided into two cohorts: cohort A with B7-H3-positive relapsed/refractory non-brainstem primary CNS tumors, and cohort B with diffuse midline gliomas (DMG). Participants will receive four (4) B7-H3-CAR T cell infusions over a 4 week period. The purpose of this study is to find the maximum (highest) dose of B7-H3-CAR T cells that are safe to give patients with primary brain tumors. Primary objectives * To determine the safety, maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) for the locoregional delivery of autologous B7-H3-CAR T cells in patients ≤ 21 years of age with recurrent/refractory B7-H3+ primary CNS tumors (Cohort A) or DMG (Cohort B). Secondary objectives * To assess the efficacy, defined as sustained objective response, a partial response (PR) or complete response (CR) observed anytime on active treatment with B7-H3-CAR T cells in patients with relapsed/refractory B7-H3+ primary CNS tumors (Cohort A) or DMG (Cohort B). * To characterize and monitor neurologic toxicities in patients while on study (Cohort A and B).

Recruiting

1 award

Phase 1

More about Christopher DeRenzo, MD

Clinical Trial Related

2 years of experience running clinical trials · Led 1 trial as a Principal Investigator · 1 Active Clinical Trial

Treatments Christopher DeRenzo, MD has experience with

  • B7-H3-CAR T Cells

Breakdown of trials Christopher DeRenzo, MD has run

Brain Tumor

Glioblastoma

Papillary Ependymoma

Solid Tumors

Rhabdoid Tumor

Other Doctors you might be interested in

Frequently asked questions

Do I need insurance to participate in a trial?

What does Christopher DeRenzo, MD specialize in?

Is Christopher DeRenzo, MD currently recruiting for clinical trials?

Are there any treatments that Christopher DeRenzo, MD has studied deeply?

What is the best way to schedule an appointment with Christopher DeRenzo, MD?

Is there any support for travel costs?

Unbiased Results

We believe in providing patients with all the options.

Your Data Stays Your Data

We only share your information with the clinical trials you're trying to access.

Verified Trials Only

All of our trials are run by licensed doctors, researchers, and healthcare companies.