Casey Halpern, M.D., Assistant ...

Dr. Casey Halpern, MD

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Standord University Medical Center

Studies Parkinson's Disease
Studies Insomnia
6 reported clinical trials
6 drugs studied

Affiliated Hospitals

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Standord University Medical Center

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Stanford University Medical Center

Clinical Trials Casey Halpern, MD is currently running

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Exablate Pallidotomy

for Parkinson's Disease

This registry is a prospective, multicenter, international, single arm, observational post-approval registry with follow-up at 3, 6, and 12 months, and annually for 5 years. The proposed registry will enroll 60 subjects and will be conducted at approximately 10 centers worldwide.

Recruiting

1 award

N/A

4 criteria

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Neurostimulation

for Sleep Problems in Parkinson's Disease

Parkinson's Disease (PD) is the second most common of the age-related neurodegenerative disorders, affecting over 1,900 adults per 100,000 over the age of 80 in the US. The prevalence of sleep dysfunction in PD is estimated at nearly 80-90% which includes sleep fragmentation, insomnia, rapid eye movement (REM or dream sleep) Sleep Behavior Disorder (RBD), Restless legs syndrome (RLS), periodic limb movement, excessive daytime sleepiness, and sleep apnea. Sleep is vital to homeostasis, cognition, and nervous system repair. The dysfunctional sleep accompanying PD adversely affects both motor and non-motor symptoms, resulting in diminished quality of life for both patients and caregivers, including impairments in mood and behavior, and increased morbidity and mortality. Knowledge of sleep phenomenology and pathology in humans has largely been informed by analysis of non-invasive scalp electroencephalogram (EEG), and despite the profound importance of sleep, the underlying neural circuits important for controlling sleep and wakefulness in humans remain poorly understood. This study assesses whether adaptive stimulation of the Subthalamic Nucleus (STN) drives changes in sleep episode maintenance and improves sleep quality. Participants are adults with PD who experience inadequate motor symptom relief, and who have been offered implantation of a deep brain stimulator system targeting STN for the treatment of motor symptoms (standard-of-care). Prior to surgery, participant sleep patterns will be assessed with questionnaires and monitored with a non-invasive watch-like device. Approximately four months after implantation surgery, participants will each receive 2 1-week deep brain stimulation (DBS) treatments and 1 1-week control session with no DBS in random order. Sleep patterns will again be monitored during the treatments and compared to the patterns before surgery.

Recruiting

1 award

N/A

11 criteria

More about Casey Halpern, MD

Clinical Trial Related

3 years of experience running clinical trials · Led 6 trials as a Principal Investigator · 3 Active Clinical Trials

Treatments Casey Halpern, MD has experience with

  • Sub-clinical Stimulation
  • Visualase MRI-Guided Laser Ablation
  • Deep Brain Stimulation
  • Responsive Neurostimulation
  • Bilateral Stimulation Of Subcallosal Cingulate White Matter (SCCwm) Using Deep Brain Stimulation (DBS)
  • Exablate Pallidotomy

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