Carl T. D'Angio, M.D. | UR Medicine

Dr. Carl T D'Angio, MD

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University of Rochester

Studies Premature Infants
Studies Preterm Birth
10 reported clinical trials
16 drugs studied

Affiliated Hospitals

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University Of Rochester
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Golisano Children's Hospital At University Of Rochester

Clinical Trials Carl T D'Angio, MD is currently running

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Antibiotics

for Neonatal Infections

The goal of the NANO trial is to study the longstanding clinical practice of empirically administering intravenous antibiotics to extremely low birthweight (ELBW) infants in the first days of life. In this 802-subject multicenter placebo-controlled randomized clinical trial, the hypothesis to be tested is that the incidence of adverse outcomes is higher in babies receiving empiric antibiotics (EA) in the first week of life compared to babies receiving placebo. The study targets a population of ELBW infants in whom the clinical decision to use or not use EA is currently most challenging -- infants that are clinically stable that did not have a known exposure to intraamniotic infection and were not born preterm for maternal indications. The primary outcome is the composite outcome of late-onset sepsis (LOS), necrotizing enterocolitis (NEC), or death during the index hospitalization. Secondary safety outcomes will include total antibiotic days, days to full enteral feedings, and common morbidities in preterm infants that have previously been linked to EA, e.g. retinopathy of prematurity and bronchopulmonary dysplasia. Weight and length z-score, and head circumference, are standard measures to be collected weekly by clinical team per a standardized protocol.
Recruiting2 awards Phase 41 criteria

More about Carl T D'Angio, MD

Clinical Trial Related6 years of experience running clinical trials · Led 10 trials as a Principal Investigator · 3 Active Clinical Trials
Treatments Carl T D'Angio, MD has experience with
  • None
  • Placebo
  • Ampicillin
  • Liberal Cell Transfusion
  • Restricted Red Cell Transfusion
  • Caffeine Citrate
Breakdown of trials Carl T D'Angio, MD has run
Premature Infants
Preterm Birth
Low Birth Weight
Small for Gestational Age
Bronchopulmonary Dysplasia

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