Bradley McGregor, MD - Dana-Farber ...

Dr. Bradley A McGregor, MD

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Dana Farber Cancer Institute

Studies Kidney Cancer
Studies Renal Cell Carcinoma
7 reported clinical trials
12 drugs studied

Affiliated Hospitals

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Dana Farber Cancer Institute

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Brigham & Womans Hospital

Clinical Trials Bradley A McGregor, MD is currently running

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Sacituzumab Govitecan + Enfortumab Vedotin

for Bladder Cancer

Phase I of this research study will assess what doses of Sacituzumab Govitecan and Enfortumab Vedotin can be safely combined in the treatment of metastatic urothelial carcinoma (mUC). In Phase II of the study, patients in one of the two cohorts will receive Sacituzumab Govitecan, Enfortumab Vedotin, and Pembrolizumab to assess the efficacy of this drug combination. The names of the study drugs in these investigational combinations are: * Enfortumab Vedotin * Sacituzumab Govitecan * Pembrolizumab

Recruiting

1 award

Phase 1 & 2

16 criteria

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Stereotactic Radiation + Immunotherapy

for Kidney Cancer

This phase II trial tests whether the addition of radiation to the primary tumor, typically given with stereotactic ablative radiation therapy (SABR), in combination with standard of care immunotherapy improves outcomes in patients with renal cell cancer that is not recommended for surgery and has spread from where it first started (primary site) to other places in the body (metastatic). Radiation therapy uses high energy photons to kill tumor cells and shrink tumors. Stereotactic body radiation therapy uses special equipment to position a patient and deliver radiation to tumors with high precision. This method may kill tumor cells with fewer doses of radiation over a shorter period and cause less damage to normal tissue. Immunotherapy with monoclonal antibodies, such as nivolumab, ipilimumab, avelumab, and pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Axitinib, cabozantinib, and lenvatinib are in a class of medications called antiangiogenic agents. They work by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Giving SABR in combination with standard of care immunotherapy may help shrink or stabilize the cancer in patients with renal cell cancer.

Recruiting

1 award

Phase 2

21 criteria

More about Bradley A McGregor, MD

Clinical Trial Related

5 years of experience running clinical trials · Led 7 trials as a Principal Investigator · 2 Active Clinical Trials

Treatments Bradley A McGregor, MD has experience with

  • Ipilimumab
  • Nivolumab
  • Cabozantinib
  • Enfortumab Vedotin
  • Sacituzumab Govitecan
  • TAK-228

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