Dr. Bradley DeNardo
Claim this profileRhode Island Hospital
Studies Brain Tumor
Studies Cancer
27 reported clinical trials
75 drugs studied
Area of expertise
1Brain Tumor
Stage II
Stage I
Stage IV
2Cancer
Stage I
Stage IV
Stage II
Affiliated Hospitals
Clinical Trials Bradley DeNardo is currently running
Selinexor + Radiation
for Brain Cancer
This trial tests the safety and effectiveness of combining selinexor with radiation therapy in children and young adults with aggressive brain tumors. Selinexor is a drug that blocks a protein to stop cancer cells from growing. The study aims to find the best dose and see if this combination can shrink tumors.
Recruiting1 award Phase 1 & 21 criteria
Inotuzumab Ozogamicin
for Acute Lymphoblastic Leukemia
This phase III trial studies whether inotuzumab ozogamicin added to post-induction chemotherapy for patients with High-Risk B-cell Acute Lymphoblastic Leukemia (B-ALL) improves outcomes. This trial also studies the outcomes of patients with mixed phenotype acute leukemia (MPAL), and B-lymphoblastic lymphoma (B-LLy) when treated with ALL therapy without inotuzumab ozogamicin. Inotuzumab ozogamicin is a monoclonal antibody, called inotuzumab, linked to a type of chemotherapy called calicheamicin. Inotuzumab attaches to cancer cells in a targeted way and delivers calicheamicin to kill them. Other drugs used in the chemotherapy regimen, such as cyclophosphamide, cytarabine, dexamethasone, doxorubicin, daunorubicin, methotrexate, leucovorin, mercaptopurine, prednisone, thioguanine, vincristine, and pegaspargase or calaspargase pegol work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This trial will also study the outcomes of patients with mixed phenotype acute leukemia (MPAL) and disseminated B lymphoblastic lymphoma (B-LLy) when treated with high-risk ALL chemotherapy. The overall goal of this study is to understand if adding inotuzumab ozogamicin to standard of care chemotherapy maintains or improves outcomes in High Risk B-cell Acute Lymphoblastic Leukemia (HR B-ALL). The first part of the study includes the first two phases of therapy: Induction and Consolidation. This part will collect information on the leukemia, as well as the effects of the initial treatment, to classify patients into post-consolidation treatment groups. On the second part of this study, patients with HR B-ALL will receive the remainder of the chemotherapy cycles (interim maintenance I, delayed intensification, interim maintenance II, maintenance), with some patients randomized to receive inotuzumab. The patients that receive inotuzumab will not receive part of delayed intensification. Other aims of this study include investigating whether treating both males and females with the same duration of chemotherapy maintains outcomes for males who have previously been treated for an additional year compared to girls, as well as to evaluate the best ways to help patients adhere to oral chemotherapy regimens. Finally, this study will be the first to track the outcomes of subjects with disseminated B-cell Lymphoblastic Leukemia (B-LLy) or Mixed Phenotype Acute Leukemia (MPAL) when treated with B-ALL chemotherapy.
Recruiting2 awards Phase 3
More about Bradley DeNardo
Clinical Trial Related3 years of experience running clinical trials · Led 27 trials as a Principal Investigator · 16 Active Clinical TrialsTreatments Bradley DeNardo has experience with
- Cyclophosphamide
- Irinotecan
- Radiation Therapy
- Etoposide
- Temozolomide
- Abemaciclib
Breakdown of trials Bradley DeNardo has run
Brain Tumor
Cancer
Brain Cancer
Rhabdomyosarcoma
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Bradley DeNardo specialize in?
Bradley DeNardo focuses on Brain Tumor and Cancer. In particular, much of their work with Brain Tumor has involved Stage II patients, or patients who are Stage I.
Is Bradley DeNardo currently recruiting for clinical trials?
Yes, Bradley DeNardo is currently recruiting for 16 clinical trials in Providence Rhode Island. If you're interested in participating, you should apply.
Are there any treatments that Bradley DeNardo has studied deeply?
Yes, Bradley DeNardo has studied treatments such as Cyclophosphamide, Irinotecan, Radiation Therapy.
What is the best way to schedule an appointment with Bradley DeNardo?
Apply for one of the trials that Bradley DeNardo is conducting.
What is the office address of Bradley DeNardo?
The office of Bradley DeNardo is located at: Rhode Island Hospital, Providence, Rhode Island 02903 United States. This is the address for their practice at the Rhode Island Hospital.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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