Armin Ghobadi, MD - Washington ...

Dr. Armin Ghobadi, M.D.

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Washington University School of Medicine

Studies Lymphoma
Studies Acute Myelogenous Leukemia
32 reported clinical trials
44 drugs studied

Area of expertise

1Lymphoma
Armin Ghobadi, M.D. has run 8 trials for Lymphoma. Some of their research focus areas include:
CD7 positive
CD20 positive
IDH positive
2Acute Myelogenous Leukemia
Armin Ghobadi, M.D. has run 8 trials for Acute Myelogenous Leukemia. Some of their research focus areas include:
CD7 positive
FLT3 negative
CEBPA positive

Affiliated Hospitals

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Washington University School Of Medicine
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Washington University In St. Louis

Clinical Trials Armin Ghobadi, M.D. is currently running

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Mosunetuzumab

for Aggressive B-Cell Lymphoma

This phase 1 pilot study examines the feasibility and safety of mosunetuzumab after autologous stem cell transplant for patients with aggressive B cell lymphomas. Mosunetuzumab is an antibody that has been engineered to attach to two target cells in the immune system: T cells that normally perform tasks like killing virus-infected cells, and cancerous B cells. Mosunetuzumab has been designed to direct these T cells to kill the cancerous B cells instead.
Recruiting2 awards Phase 1
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CAR-T Therapy

for Multiple Myeloma

Despite recent therapeutic advances, multiple myeloma (MM) remains an incurable disease. Although survival has improved, there are nevertheless diminishing durations of response to each subsequent line of therapy. This highlights the need for further therapeutic innovation. BCMA-targeting CAR-T cells show impressive response rates; however, their median duration of response is disappointing. The investigators propose that CS1(SLAMF7)-targeting CAR-T cells will fill a gap in the MM armamentarium. CS1 is an attractive target in MM because it is expressed in most patients. Elotuzumab (Empliciti®), an approved anti-CS1 antibody, has proven the clinical efficacy of this target. CAR-T cells are an ideal modality to target CS1, given that two approved treatments, ide-cel (idecabtagene vicleucel, AbecmaTM) and cilta-cel (ciltacabtagene autoleucel, Carvykti™), have proven the potential for cellular immunotherapy in MM. The investigators are testing the safety and preliminary anti-myeloma efficacy of WS-CART-CS1, a CAR-T cell therapy targeting CS1.
Recruiting1 award Phase 1

More about Armin Ghobadi, M.D.

Clinical Trial Related3 years of experience running clinical trials · Led 32 trials as a Principal Investigator · 9 Active Clinical Trials
Treatments Armin Ghobadi, M.D. has experience with
  • WU-CART-007
  • Mosunetuzumab
  • Tabelecleucel
  • Cytokine Induced Memory-like NK Cell Adoptive Therapy
  • Isatuximab
  • Nivolumab

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