Dr. Anthony F. Shields
Claim this profileBarbara Ann Karmanos Cancer Institute
Studies Cancer
Studies Solid Tumors
22 reported clinical trials
65 drugs studied
Area of expertise
1Cancer
Stage IV
Stage III
dMMR positive
2Solid Tumors
Stage IV
Stage III
dMMR positive
Affiliated Hospitals
Clinical Trials Anthony F. Shields is currently running
TAB004 + Toripalimab
for Solid Cancers
The primary objective is to assess the safety and tolerability of TAB004 as monotherapy and in combination with toripalimab in subjects with selected advanced solid malignancies, including lymphoma, and to evaluate the recommended Phase 2 dose. The secondary objectives are to: 1) describe the pharmacokinetic (PK) profile of TAB004 monotherapy and in combination with toripalimab and to describe the PK profile of toripalimab when administered with TAB004, 2) evaluate antitumor activity of TAB004 monotherapy and in combination with toripalimab; and 3) determine the immunogenicity of TAB004 monotherapy and in combination with toripalimab and to determine the immunogenicity of toripalimab when administered with TAB004. The exploratory objectives are to: 1) evaluate pharmacodynamic effects of TAB004 on its target receptor BTLA, as well as effects on the immune system; 2) evaluate biomarkers that may correlate with activity of TAB004 as monotherapy and in combination with toripalimab; 3) evaluate the utility of BTLA ligand, herpesvirus-entry mediator (HVEM), and additional exploratory biomarkers that could aid in selection of appropriate subjects for TAB004 monotherapy and in combination with toripalimab.
Recruiting1 award Phase 110 criteria
Gemcitabine + Nab-paclitaxel + TheraBionic P1
for Pancreatic Cancer
The goal of this study is to learn if the combination of nab-paclitaxel, gemcitabine and an Amplitude-Modulated Radiofrequency Electromagnetic Fields device (Therabionic P1) is safe and effective for patients with adenocarcinoma of the pancreas.
Recruiting1 award Phase 24 criteria
More about Anthony F. Shields
Clinical Trial Related5 years of experience running clinical trials · Led 22 trials as a Principal Investigator · 9 Active Clinical TrialsTreatments Anthony F. Shields has experience with
- Gemcitabine
- Ipilimumab
- Capecitabine
- Fluorouracil
- Nivolumab
- Leucovorin
Breakdown of trials Anthony F. Shields has run
Cancer
Solid Tumors
Pancreatic Cancer
Colorectal Cancer
Cervical Adenocarcinoma
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