Dr. Aine E. Clements
Claim this profileOhioHealth Mansfield Hospital
Studies Endometrial Cancer
Studies Ovarian Cancer
7 reported clinical trials
32 drugs studied
Area of expertise
1Endometrial Cancer
Stage IV
Stage III
HRAS positive
2Ovarian Cancer
KRAS positive
Stage IV
NRAS positive
Affiliated Hospitals
Clinical Trials Aine E. Clements is currently running
Chemotherapy
for Cancer
This phase III trial studies how well active surveillance help doctors to monitor subjects with low risk germ cell tumors for recurrence after their tumor is removed. When the germ cell tumor has spread outside of the organ in which it developed, it is considered metastatic. Chemotherapy drugs, such as bleomycin, carboplatin, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The trial studies whether carboplatin or cisplatin is the preferred chemotherapy to use in treating metastatic standard risk germ cell tumors.
Recruiting2 awards Phase 326 criteria
Selumetinib + Olaparib
for Ovarian and Endometrial Cancer
This phase II ComboMATCH treatment trial compares selumetinib plus olaparib to selumetinib alone in women with endometrial or ovarian (fallopian tube and primary peritoneal) cancer that has come back (recurrent) or that remains despite treatment (persistent) and harbors a mutation in the RAS pathway. Selumetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Olaparib is an inhibitor of PARP, an enzyme that helps repair deoxyribonucleic acid (DNA) when it becomes damaged. Blocking PARP may help keep tumor cells from repairing their damaged DNA, causing them to die. PARP inhibitors are a type of targeted therapy. The addition of olaparib to selumetinib could increase the percentage of tumors that shrink as well as lengthen the time that the tumors remain stable (without progression) as compared to selumetinib alone.
Recruiting1 award Phase 2
More about Aine E. Clements
Clinical Trial Related2 years of experience running clinical trials · Led 7 trials as a Principal Investigator · 4 Active Clinical TrialsTreatments Aine E. Clements has experience with
- Binimetinib
- Ipatasertib
- Olaparib
- Palbociclib
- Selumetinib Sulfate
- Everolimus
Breakdown of trials Aine E. Clements has run
Endometrial Cancer
Ovarian Cancer
Cervical Adenocarcinoma
Relapse
Parotid Gland Cancer
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