Search hospitals > Illinois > Chicago

Northwestern University Feinberg School of Medicine

Claim this profile
Chicago, Illinois 60611
Global Leader in HIV Infection
Global Leader in Human Immunodeficiency Virus Infection
Conducts research for AIDS
Conducts research for Cancer
Conducts research for Breast Cancer
491 reported clinical trials
41 medical researchers
Photo of Northwestern University Feinberg School of Medicine in ChicagoPhoto of Northwestern University Feinberg School of Medicine in ChicagoPhoto of Northwestern University Feinberg School of Medicine in Chicago

Summary

Northwestern University Feinberg School of Medicine is a medical facility located in Chicago, Illinois. This center is recognized for care of HIV Infection, Human Immunodeficiency Virus Infection, AIDS, Cancer, Breast Cancer and other specialties. Northwestern University Feinberg School of Medicine is involved with conducting 491 clinical trials across 571 conditions. There are 41 research doctors associated with this hospital, such as Sunandana Chandra, Amy Paller, Thomas Schnitzer, and Devalingam Mahalingam, MBBChBAO.

Top PIs

Clinical Trials running at Northwestern University Feinberg School of Medicine

Intermittent Claudication
Peripheral Vascular Disease
Breast Cancer
Peripheral Arterial Disease
Limited Mobility
Peripheral Artery Disease
Lung Cancer
Atopic Dermatitis
Obesity
Cancer
Image of trial facility.

Exercise and Beetroot Juice

for Peripheral Arterial Disease

Lower extremity revascularization combined with supervised exercise significantly improves walking performance compared to revascularization alone in people who have PAD without limb threatening ischemia. However, supervised exercise is inaccessible or burdensome for most PAD patients. Investigators hypothesize that home-based exercise combined with lower extremity revascularization will significantly improve walking performance compared to revascularization alone in patients with PAD undergoing revascularization for disabling PAD. Investigators further hypothesize that inorganic nitrate, a major source of nitric oxide (NO) abundant in beetroot juice, will improve walking performance after lower extremity revascularization, compared to placebo. In preclinical models, NO inhibits inflammation, neointimal hyperplasia, thrombosis, and vascular smooth muscle cell migration at sites of revascularization. NO increases angiogenesis and perfusion, repairs skeletal muscle damaged by ischemia, and stimulates mitochondrial activity. In a randomized clinical trial with a 2 x 2 factorial design, the trial will test the following two primary hypotheses in 386 patients randomized within three months of a successful lower extremity revascularization for disabling PAD: First, that home-based exercise combined with lower extremity revascularization will improve six-minute walk distance more than revascularization alone at 6-month follow-up (Primary Aim #1). Second, that nitrate-rich beetroot juice combined with lower extremity revascularization will improve six-minute walk, compared to placebo combined with revascularization at 6-month follow-up (Primary Aim #2).
Recruiting1 award Phase 31 criteria
Image of trial facility.

Fisetin

for PAD

The investigators propose a pilot randomized trial to gather preliminary data to test the hypothesis that Fisetin will reduce abundance of senescent cells in blood, skeletal muscle, and both subcutaneous and inter muscular adipose tissue and improve 6-minute walk distance in 34 people with peripheral artery disease (PAD). the investigators will determine whether greater declines in abundance of cells with senescent markers are associated with greater improvement in 6-minute walk distance in people with peripheral artery disease. In exploratory analyses, the investigators will assess whether Fisetin reduces interleukin-6 (IL-6) and novel senescent markers in adipose tissue, muscle, and/or blood.
Recruiting0 awards Phase 22 criteria
Image of trial facility.

Exercise and Beetroot Juice

for Peripheral Artery Disease

RESIST PAD is a randomized trial of 200 PAD patients to establish: 1) whether a 12-week exercise intervention significantly increases Δ nitrite at 12-week follow-up, compared to control; 2) whether exercise "responders" have greater Δ nitrite increases compared to "non-responders"; 3) among non-responders, whether supplementing exercise with nitrate-rich beetroot juice between weeks 13-24 increases Δ nitrite and improves 6-minute walk at 24-week follow-up.
Recruiting0 awards Phase 22 criteria

Similar Hospitals nearby

Frequently asked questions

What kind of research happens at Northwestern University Feinberg School of Medicine?
Where is Northwestern University Feinberg School of Medicine located?
Who should I call to ask about financial aid or insurance network?
What insurance does Northwestern University Feinberg School of Medicine accept?
What awards or recognition has Northwestern University Feinberg School of Medicine received?
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Terms of Service·Privacy Policy·Cookies·Security
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Terms of Service·Privacy Policy·Cookies·Security