Iowa City VA Health Care System, Iowa City, IA

Summary

Iowa City VA Health Care System, Iowa City, IA is a medical facility located in Iowa City, Iowa. This center is recognized for care of Lung Cancer, Prostate Cancer, Hypertension, Diabetes, Depression and other specialties. Iowa City VA Health Care System, Iowa City, IA is involved with conducting 77 clinical trials across 137 conditions. There are 7 research doctors associated with this hospital, such as Chandrikha Chandrasekharan, MBBS, Diana Jalal, MD, David Katz, MD, and Marion L Sanders, MD.

Top PIs

Clinical Trials running at Iowa City VA Health Care System, Iowa City, IA

Chronic Kidney Disease

Atherosclerosis

Renal Disease

Rejection Sensitivity

Proteinuria

Diabetes

Kidney Transplant

Cardiovascular Disease

Chronic Renal Failure

Kidney Failure

Empagliflozin

for Kidney Transplant Recipients

Kidney transplantation improves the health and quality of life for those Veterans with end stage kidney disease (ESKD). While early patient and graft survival are excellent, long-term outcomes continue to be challenging. Patient death with existing kidney graft function occurs in about half of all recipients over time. This is primarily due to the development of cardiovascular disease in a patient population with multiple preexisting cardiac disease risk factors. There has been little progress in improving outcomes in this area for over two decades. Recent studies in chronic kidney disease (CKD) patients using SGLT2 inhibitors (SGLT2i), regardless of the presence of type 2 diabetes mellitus (T2DM), results in both kidney protective and cardiac protective impacts and improved patient outcomes. However, kidney transplant recipients (KTRs) were excluded from these clinical trials due to concerns that these agents promote infection, diminish graft function, and may alter immunosuppressive drug levels that are the mainstay of patient's transplant therapy. There are limited published data of SGLT2i treatment of selected KTRs.

Recruiting

3 awards

Phase 4

6 criteria

Self-Managed Blood Pressure Control

for Chronic Kidney Disease

The proposed research will evaluate if patients managing their blood pressure medications under the guidance of a clinical pharmacist works better to lower blood pressure than patients monitoring their blood pressure at home and the standard care. 60 Veterans with chronic kidney disease (CKD) will be included in the study. The study will further evaluate factors that may influence the Veteran to accept the self-management approach and what factors in the VHA healthcare system affect the implementation of the self-management approach.

Recruiting

2 awards

Phase 3

3 criteria