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Craig Hospital
Claim this profileEnglewood, Colorado 80113
Global Leader in Spinal Cord Injury
Global Leader in Traumatic Brain Injury
Conducts research for Cervical Cord Injury
Conducts research for Endothelial Dysfunction
Conducts research for Pain
39 reported clinical trials
0 medical researchers
Summary
Craig Hospital is a medical facility located in Englewood, Colorado. This center is recognized for care of Spinal Cord Injury, Traumatic Brain Injury, Cervical Cord Injury, Endothelial Dysfunction, Pain and other specialties. Craig Hospital is involved with conducting 39 clinical trials across 42 conditions. There are 0 research doctors associated with this hospital, such as .Top PIs
Clinical Trials running at Craig Hospital
Spinal Cord Injury
Endothelial Dysfunction
Cardiovascular Disease
Traumatic Brain Injury
Cognitive Impairment
Pararenal Aneurysms
Low Testosterone
Bowel Incontinence
Neurogenic Bowel
Hypertension
Endothelial Function Treatment
for Spinal Cord Injury
Individuals with spinal cord injury have heart attacks and strokes more frequently, and much earlier in life. People with spinal cord injuries develop plaque in vessels much faster, and the reasons why are unclear. Doctors generally attributed the increased risk with weight gain and developing diabetes, but many studies have shown that even without these common factors, plaque in vessels is developing more often and faster. Endothelial cells are a single layer of cells that line all vessels in the body and plays an important role in vessel health. Damage to endothelial cells is known to lead to heart attacks and strokes. Past studies on endothelial cells of people with spinal cord injury have been unclear. The investigators have new data that these cells are unhealthy after spinal cord injury a measurement. This includes measuring endothelial health by directly altering its function using a catheter in the arm and measuring small particles in blood called endothelial microvesicles. If the project is successful, the investigators will learn important information on the health of endothelial cells after spinal cord injury. The investigators will also be able to use these markers of endothelial cell function to create treatments to improve vessel health and prevent heart attacks and strokes later in life in people with spinal cord injury.
Recruiting1 award N/A4 criteria
Vasoactive Agents
for Endothelial Dysfunction After Spinal Cord Injury
This study plans to learn how endothelial cells, single cell lining of blood vessels may be dysfunctional after a spinal cord injury. Endothelial dysfunction will be measured by the capacity of blood vessels to vasodilate (increase in size) and alter blood flow is lower in adults with a spinal cord injury in comparison to adults without a spinal cord injury. The mechanisms which may alter this function may be critical in reducing the risk of heart attacks and strokes in people with spinal cord injuries.
Recruiting1 award N/A7 criteria
Testosterone
for Spinal Cord Injury
Heart attacks and strokes are among the most common causes of premature death in individuals living with spinal cord injury (SCI) and appear to occur earlier in life. The factors that lead to the heighten and accelerated risk of heart attacks and strokes in adults living with SCI remain poorly understood. The investigators aim to uncover why this happens and find ways to prevent it. Our research focuses on how important cells which line blood vessels, called endothelial cells, function after SCI. The investigators test endothelial function in live conscious people with SCI. The investigators also study signaling molecules endothelial cells release called endothelial cell derived microvesicles (EMVs), which the investigators can measure in blood to tell us the health of endothelial cells. By using these rigorous tests of vascular function, the investigators have determined that endothelial cells appear dysfunctional after SCI. The investigators also know that many men with SCI have low testosterone levels. Our team has studied testosterone's effects on endothelial dysfunction and believe low testosterone may be contributing to endothelial dysfunction after SCI. By understanding these mechanisms, the investigators hope to improve the lives of those living with SCI and reduce their risk for heart attacks and strokes. The investigators propose to study the influence of testosterone on endothelial function by using state-of-the-art clinical and laboratory experiments to assess endothelial function in men with SCI with low and normal testosterone levels.
Recruiting1 award N/A5 criteria
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Frequently asked questions
What kind of research happens at Craig Hospital?
Craig Hospital is a medical facility located in Englewood, Colorado. This center is recognized for care of Spinal Cord Injury, Traumatic Brain Injury, Cervical Cord Injury, Endothelial Dysfunction, Pain and other specialties. Craig Hospital is involved with conducting 39 clinical trials across 42 conditions. There are 0 research doctors associated with this hospital, such as .
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.