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Children's Hospital Colorado

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Aurora, Colorado 80045

Global Leader in Cancer

Global Leader in Brain Tumor

Conducts research for Neuroblastoma

Conducts research for Solid Tumors

Conducts research for Cystic Fibrosis

1053 reported clinical trials

85 medical researchers

Photo of Children's Hospital Colorado in AuroraPhoto of Children's Hospital Colorado in AuroraPhoto of Children's Hospital Colorado in Aurora

Summary

Children's Hospital Colorado is a medical facility located in Aurora, Colorado. This center is recognized for care of Cancer, Brain Tumor, Neuroblastoma, Solid Tumors, Cystic Fibrosis and other specialties. Children's Hospital Colorado is involved with conducting 1,053 clinical trials across 1,443 conditions. There are 85 research doctors associated with this hospital, such as Margaret E. Macy, Kathleen Dorris, MD, Navin Pinto, MD, and Kelly W. Maloney.

Area of expertise

1

Cancer

Global Leader

Children's Hospital Colorado has run 102 trials for Cancer. Some of their research focus areas include:

Stage IV
Stage I
Stage II
2

Brain Tumor

Global Leader

Children's Hospital Colorado has run 84 trials for Brain Tumor. Some of their research focus areas include:

NTRK positive
BRAF positive
Stage IV

Top PIs

Clinical Trials running at Children's Hospital Colorado

Testicular cancer

Brain Tumor

Neuroblastoma

Prader-Willi Syndrome

Leukemia

Spinal Muscular Atrophy

Chronic Kidney Disease

Wilms Tumor

Ovarian Carcinoma

Ovarian Tumors

Image of trial facility.

Chemotherapy

for Cancer

This phase III trial studies how well active surveillance help doctors to monitor subjects with low risk germ cell tumors for recurrence after their tumor is removed. When the germ cell tumor has spread outside of the organ in which it developed, it is considered metastatic. Chemotherapy drugs, such as bleomycin, carboplatin, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The trial studies whether carboplatin or cisplatin is the preferred chemotherapy to use in treating metastatic standard risk germ cell tumors.

Recruiting

2 awards

Phase 3

26 criteria

Image of trial facility.

Chemotherapy + Radiation Therapy

for Brain Cancer

This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in patients with non-germinomatous germ cell tumors (NGGCT) that have not spread to other parts of the brain or body (localized). This study has 2 goals: 1) optimizing radiation for patients who respond well to induction chemotherapy to diminish spinal cord relapses, 2) utilizing higher dose chemotherapy followed by conventional RT in patients who did not respond to induction chemotherapy. Chemotherapy drugs, such as carboplatin, etoposide, ifosfamide, and thiotepa, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays or high-energy protons to kill tumor cells and shrink tumors. Studies have shown that patients with newly-diagnosed localized NGGCT, whose disease responds well to chemotherapy before receiving radiation therapy, are more likely to be free of the disease for a longer time than are patients for whom the chemotherapy does not efficiently eliminate or reduce the size of the tumor. The purpose of this study is to see how well the tumors respond to induction chemotherapy to decide what treatment to give next. Some patients will be given RT to the spine and a portion of the brain. Others will be given high dose chemotherapy and a stem cell transplant before RT to the whole brain and spine. Giving treatment based on the response to induction chemotherapy may lower the side effects of radiation in some patients and adjust the therapy to a more efficient one for other patients with localized NGGCT.

Recruiting

1 award

Phase 2

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