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Vitamin Supplement

Vitamin K1 500 µg for Osteoarthritis

N/A

Waitlist Available

Led By Jean Liew, MD MS

Research Sponsored by Boston University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Clinical diagnosis of knee OA by the treating rheumatologist

≥60 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 4 weeks

Awards & highlights

Study Summary

This trial aims to test different types and doses of vitamin K supplements in older adults with knee osteoarthritis. The goal is to determine if vitamin K can improve outcomes related to knee osteoar

Who is the study for?

This trial is for older adults who have knee osteoarthritis. It's designed to see if different types and doses of vitamin K can help with the condition. To join, participants must meet certain health criteria that aren't specified here.Check my eligibility

What is being tested?

The study tests two forms of vitamin K (K1 at 1000 µg or 500 µg daily, and K2 as MK-7 at 360 µg daily) against a placebo to find out which one might improve knee OA outcomes. Participants will be randomly assigned to receive one of these options.See study design

What are the potential side effects?

While specific side effects are not listed, typical reactions to supplements like vitamin K could include changes in blood clotting ability, allergic reactions, or gastrointestinal discomfort.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

My rheumatologist diagnosed me with knee osteoarthritis.

Select...

I am 60 years old or older.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 4 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~4 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in menaquinone-7 (MK-7) levels

Change in phylloquinone levels

Change in uncarboxylated matrix Gla protein (ucMGP) levels

+1 more

Secondary outcome measures

Participant acceptability of intervention

Study adherence

Trial Design

4Treatment groups

Experimental Treatment

Placebo Group

Group I: Vitamin K2 (MK-7) 360 µgExperimental Treatment1 Intervention

Participants randomized to this arm will take one Vitamin K2 (MK-7) 360 µg pill daily for 4 weeks.

Group II: Vitamin K1 500 µgExperimental Treatment1 Intervention

Participants randomized to this arm will take one Vitamin K1 500 µg pill daily for 4 weeks.

Group III: Vitamin K1 1000 µgExperimental Treatment1 Intervention

Participants randomized to this arm will take one Vitamin K1 1000 µg pill daily for 4 weeks.

Group IV: PlaceboPlacebo Group1 Intervention

Participants randomized to this arm will take 1 placebo pill daily for 4 weeks.

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Boston UniversityLead Sponsor

457 Previous Clinical Trials

9,941,803 Total Patients Enrolled

12 Trials studying Osteoarthritis

5,930 Patients Enrolled for Osteoarthritis

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)NIH

485 Previous Clinical Trials

1,086,844 Total Patients Enrolled

51 Trials studying Osteoarthritis

46,981 Patients Enrolled for Osteoarthritis

Jean Liew, MD MSPrincipal InvestigatorBoston University Chobanian & Avedisian School of Medicine, Department of Rheumatology

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are patients currently being enrolled in this ongoing medical study?

"Data from clinicaltrials.gov indicates that this particular trial is presently not in recruitment phase. It was initially posted on July 1, 2024 and last revised on April 24, 2024. Despite its current inactive status, there are currently a total of 693 other trials actively seeking participants."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

The Role of Vitamin K on Knee Osteoarthritis Outcomes

2024. "The Role of Vitamin K on Knee Osteoarthritis Outcomes". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06385275.

All > Knee Osteoarthritis