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DNA Methylation Modifier
Exercise Training for Vascular Dysfunction in Obesity
N/A
Recruiting
Led By Abeer Mohamed, MD, PhD
Research Sponsored by University of Illinois at Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Between ages 18-50 years
Approved for a bariatric surgery
Timeline
Screening 3 weeks
Treatment Varies
Follow Up month 24-30
Awards & highlights
Study Summary
This trial is testing if reducing inflammation through exercise can help improve vascular function in obese people.
Who is the study for?
This trial is for adults aged 18-50 with severe obesity (BMI ≥ 35 kg/m2) who are approved for bariatric surgery but not currently pregnant. It excludes those with cancer, heart, kidney or liver diseases, gallbladder disease, inflammatory/autoimmune conditions, smokers, and substance abusers.Check my eligibility
What is being tested?
The study investigates if aerobic exercise can improve blood vessel function and reduce inflammation in obese individuals by altering DNA methylation—a process affecting gene activity without changing the DNA sequence itself.See study design
What are the potential side effects?
While specific side effects are not listed for exercise training interventions in this context, typical risks may include muscle soreness, fatigue, joint pain or injury. The intensity of these side effects varies from person to person.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am between 18 and 50 years old.
Select...
I am approved for weight loss surgery.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ month 24-30
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~month 24-30
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
DNA methylation status of adipocytokines in obese individuals
Secondary outcome measures
Flow induced dilation
Vascular health biomarkers in obese individuals before and after exercise training
Trial Design
2Treatment groups
Active Control
Group I: ExercisingActive Control1 Intervention
12 weeks of aerobic exercise training
Group II: Non-exercisingActive Control1 Intervention
standard of care
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Who is running the clinical trial?
University of Illinois at ChicagoLead Sponsor
611 Previous Clinical Trials
1,560,485 Total Patients Enrolled
33 Trials studying Obesity
9,743 Patients Enrolled for Obesity
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,847 Previous Clinical Trials
47,818,566 Total Patients Enrolled
251 Trials studying Obesity
205,928 Patients Enrolled for Obesity
Abeer Mohamed, MD, PhDPrincipal InvestigatorUniversity of Illinois at Chicago
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Eligibility Criteria:
This trial includes the following eligibility criteria:- I have a current diagnosis of cancer, heart, kidney, liver, gallbladder disease, or an inflammatory/autoimmune condition.I am between 18 and 50 years old.I am approved for weight loss surgery.
Research Study Groups:
This trial has the following groups:- Group 1: Exercising
- Group 2: Non-exercising
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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