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Open-label Placebo for Depression (OLP Trial)
OLP Trial Summary
This trial is testing whether non-deceptive placebos (open-label placebo, OLP) can help relieve symptoms of depression in adolescents. The investigators think that the mechanism by which OLP exerts its action in adolescent depression is by forming a positive expectation, which activates endogenous mu-opioid receptor (MOR)-mediated neurotransmission in a network of regions implicated in emotion, stress regulation, and the pathophysiology of MDD, namely, the anterior cingulate cortex (ACC) - striato - amygdalo - thalamic network.
OLP Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.OLP Trial Design
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Who is running the clinical trial?
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- You are a teenager between 13-18 years old, not taking any medication, and experiencing mild to moderate depression. A mental health professional or primary care doctor is aware of your condition.You have mental health conditions other than anxiety disorder, or have severe thoughts about hurting yourself.
- Group 1: Control
- Group 2: Open Label Placebo Group with Rationale
- Group 3: Open Label Placebo Group without Rationale
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Who qualifies to participate in this research endeavor?
"This medical trial is seeking to enrol 60 adolescents with depression between the ages of 13 and 18."
Is this research open to individuals who are 35 years and older?
"According to the stated criteria for participation, eligible individuals must be aged between 13 and 18 years old. This study is one of 177 that include patients under eighteen and 849 studies involving people over 65."
Are there any available spots for participation in this clinical research?
"According to clinicaltrials.gov, this medical research effort is actively searching for participants. The study was initially listed on May 14th 2020 and the most recent edit occurred on August 8th 2022."
What is the total number of participants enrolled in this research project?
"Absolutely. According to the information provided on clinicaltrials.gov, this research project is actively seeking participants. Initially posted on May 14th 2020 and most recently updated on August 8th 2022, 60 individuals are being sought for enrollment across a single medical facility."
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