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Selective Serotonin Reuptake Inhibitor

2 for Depression

Phase 4
Waitlist Available
Led By Mark J Rapoport, MD, FRCPC
Research Sponsored by Ontario Neurotrauma Foundation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 40 weeks
Awards & highlights

Study Summary

The purpose of the study is to explore to what extent continuing the antidepressant medication citalopram (Celexa), after depression has responded to treatment, helps prevent the return of depressive symptoms in patients with recent traumatic brain injury (TBI).

Eligible Conditions
  • Depression

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~40 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 40 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
recurrence of major depression by administering the Hamilton Depression Rating Scale (HAM-D) and Clinical Global Impressions Scale (CGI) every 4 weeks for 40 weeks
Secondary outcome measures
general cognitive function at baseline, 10 weeks and on termination of the trial
list of adverse drug events at baseline, 10 weeks and on termination of the trial

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: 2Experimental Treatment1 Intervention
Group II: 1Placebo Group1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Citalopram
FDA approved

Find a Location

Who is running the clinical trial?

Ontario Neurotrauma FoundationLead Sponsor
22 Previous Clinical Trials
1,082 Total Patients Enrolled
3 Trials studying Depression
200 Patients Enrolled for Depression
Mark J Rapoport, MD, FRCPCPrincipal InvestigatorSunnybrook Health Sciences Centre, University of Toronto

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Antidepressant Maintenance in Traumatic Brain Injury
2005. "Antidepressant Maintenance in Traumatic Brain Injury". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00162916.
All > Trauma > Traumatic Brain Injury
~1 spots leftby May 2025
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