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LNA043 for Knee Osteoarthritis (ONWARDS Trial)
ONWARDS Trial Summary
This trial will help find the best dose of the drug LNA043 for people with knee osteoarthritis.
- Osteoarthritis
ONWARDS Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.ONWARDS Trial Design
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Who is running the clinical trial?
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- You have a diagnosis of primary knee OA by standard American College of Rheumatology clinical and radiographic criteria.There may be additional requirements for participation that are outlined in the study plan.You are between 40 and 75 years of age.You have a body mass index (BMI) of less than 40 kg/m2.
- Group 1: Placebo
- Group 2: LNA043 Dosing Regimen A
- Group 3: LNA043 Dosing Regimen B
- Group 4: LNA043 Dosing Regimen C
- Group 5: LNA043 Dosing Regimen D
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Has the FDA officially sanctioned LNA043 Dosing Regimen A?
"With limited data supporting efficacy, but some evidence that LNA043 Dosing Regimen A is safe, it was given a rating of 2."
Is participation in this clinical research open to the public?
"This trial is looking for 550 individuals with arthrosis between the ages of 40 and 75. To be eligible they must fulfill certain prerequisites, including: Being a male or female aged 40 to 75 years old; having a BMI lower than 40 kg/m2; being diagnosed with primary tibiofemoral knee OA according to all American College of Rheumatology clinical and radiographic criteria; as well as any other conditions specified by the protocol."
Are there any remaining opportunities for participants in this experiment?
"Affirmative. According to the clinicaltrials.gov records, recruitment for this medical trial is currently underway and began on May 31st 2021 with a most recent update posted on November 4th 2022. The study aims to enrol 550 participants at two different sites."
What is the total participant count for this research endeavor?
"Verified, the information contained on clinicaltrials.gov shows this medical trial is still in progress and new participants are being recruited since its initial posting date of May 31st 2021. The study requires 550 patients from 2 separate locations to finish successfully."
Does the trial include individuals above seventy-five years of age?
"Eligible patients for this clinical trial must fall within the age bracket of 40 to 75. Moreover, there are 38 trials that cater specifically to minors and 656 studies dedicated exclusively towards senior citizens."
Who else is applying?
What state do they live in?
How old are they?
What site did they apply to?
What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
Why did patients apply to this trial?
How responsive is this trial?
Typically responds via
Most responsive sites:
- Novartis Investigative Site: < 48 hours
Average response time
- < 2 Days
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