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Single vs Multiple Dose Radiation for Brain Metastases (HYPOGRYPHE Trial)
HYPOGRYPHE Trial Summary
This trial evaluates if a lower radiation dose over multiple days reduces side effects vs. one day of full radiation dose for cancer patients on immunotherapy.
HYPOGRYPHE Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.HYPOGRYPHE Trial Design
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Who is running the clinical trial?
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- I've had radiation for brain tumors, but they were treated far from where my current cancer would be targeted.I have had brain radiation therapy before.I am 18 years old or older.I have 15 or fewer brain tumors suitable for specific radiation treatments.My brain cancer is very close to my optic nerves.My lesion's size was estimated using a specific MRI technique.My cancer has spread to the lining of my brain or spinal cord, confirmed by tests.I have a brain tumor larger than 2 cm or 4 cc and haven't had brain radiation before.My tumor's total size is 30 cc or less, measured by MRI or treatment software.I cannot undergo an MRI with contrast for my brain.My cancer is either melanoma, kidney, lung, or breast cancer.I can do most of my daily activities by myself.My cancer has spread outside the brain and does not need to be under control to join.I have brain metastases and may or may not have received systemic therapy for it.I am undergoing or will undergo therapy targeting my immune system within 30 days.I have not taken bevacizumab within the last 30 days.
- Group 1: FSRS = fractionated stereotactic radiosurgery
- Group 2: SSRS = single fraction stereotactic radiosurgery
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
To what extent are individuals being admitted for this experiment?
"Affirmative. The clinicaltrials.gov page indicates that this investigation is currently recruiting patients. It was initially posted on 11th July 2023, and the most recent update occurred on 17th July 2023. 244 participants are being sought at 1 medical centre for trial participation."
Are there any possibilities to enroll in this research endeavor currently?
"Affirmative. The information on clinicaltrials.gov confirms that this research is currently seeking participants, having been first posted to the website on July 11th 2023 and last updated July 17th of the same year. 244 individuals are sought across 1 medical centre for inclusion in the trial."
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