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Hydroxynorketamine for Neuropathic Pain (HNK Trial)
HNK Trial Summary
This trial will evaluate the effectiveness and duration of a single infusion of (2R,6R)-HNK on pain, physical function, pain interference, sleep disturbance and quality of life in patients with neuropathic pain.
HNK Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowHNK Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.HNK Trial Design
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Who is running the clinical trial?
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- I have not had a serious illness in the last 2 weeks.I have a known liver condition.I choose not to take pain medication if I feel better.You have a serious medical condition that could make it unsafe for you to participate in the study.You have used tobacco or nicotine products in the last 4 weeks.I have been diagnosed with neuropathic pain based on a specific questionnaire.I am on medication for chronic nerve pain and agree to continue it during the study.I have difficulty with blood draws or IV insertions due to poor vein access.Your blood pressure when lying down is between 90 and 145 for the top number and no more than 90 for the bottom number.My BMI is between 18 and 35, and I weigh between 50 kg and 120 kg.I am not allergic to ketamine or any medication used in this study.I am between 18 and 80 years old with chronic nerve pain in my limbs for over 3 months.Your lab tests for liver function are normal, or if they are not, the doctor doesn't think it's a big problem.You have a current diagnosis of a mental illness.I have widespread pain or have been diagnosed with fibromyalgia.I have received ketamine for chronic pain before.You have consumed alcohol, grapefruit, poppy seeds, Brussel sprouts, pomegranate, broccoli, or char-grilled meat in the last 2 days before taking the drug.I might have high pressure in my brain or eyes.Your heart test should show no major problems, and the QTc interval (a measure of heart rhythm) should be less than 450 milliseconds.Your heart beats between 45 and 100 times per minute when you are resting.
- Group 1: Ketamine
- Group 2: (2R,6R)-hydroxynorketamine
- Group 3: Saline
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Does this research involve adults over the age of 25?
"To be eligible for this medical trial, individuals must not have exceeded 75 years of age and should at least be over 18."
What criteria must be met for individuals to join this scientific trial?
"Candidates should be aged 18-75 and suffer from neuropathic pain to qualify for the trial. The team is looking for 25 participants in total."
Are participants still being sought to join this clinical venture?
"Unfortunately, the clinical trial is not presently enrolling patients. Initially posted on January 1st 2024 and last updated May 8th 2023, it has ended its recruitment period; however, there are currently 138 other medical studies actively searching for participants."
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