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Probiotic

Probiotics for Urinary Tract Infection in Neurogenic Bladder

Phase 1 & 2
Waitlist Available
Led By Sumit Dave
Research Sponsored by London Health Sciences Centre
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 3 and 6 months
Awards & highlights

Study Summary

This trial will test whether probiotics are safe and can reduce the number of urinary tract infections and the amount of renal scarring in children with neurogenic bladder conditions who are using clean intermittent catheterization.

Eligible Conditions
  • Urinary Tract Infection

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 3 and 6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 3 and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Side effects
Secondary outcome measures
Bladder storage function
Changes in metabolomic profiles of urine
Changes in pro-inflammatory cytokines
+2 more

Trial Design

3Treatment groups
Active Control
Placebo Group
Group I: probiotics plus antibioticActive Control2 Interventions
This group will be on a dose of probiotics (2 capsules; 5 billion total organisms of L. rhamnosus GR-1 and L. reuteri RC-14 per capsule) plus a antibiotic (Septra)
Group II: AntibioticActive Control1 Intervention
This group will be prescribed a dose of antibiotics (Septra 2mg/kg)
Group III: Probiotic plus placeboPlacebo Group2 Interventions
Receive probiotic plus an antibiotic placebo

Find a Location

Who is running the clinical trial?

London Health Sciences CentreLead Sponsor
143 Previous Clinical Trials
49,926 Total Patients Enrolled
Canadian Urological AssociationIndustry Sponsor
7 Previous Clinical Trials
581 Total Patients Enrolled
Sumit DavePrincipal InvestigatorLondon Health Sciences Centre

Media Library

Probiotic (Probiotic) Clinical Trial Eligibility Overview. Trial Name: NCT02044965 — Phase 1 & 2
Urinary Tract Infection Research Study Groups: probiotics plus antibiotic, Antibiotic, Probiotic plus placebo
Urinary Tract Infection Clinical Trial 2023: Probiotic Highlights & Side Effects. Trial Name: NCT02044965 — Phase 1 & 2
Probiotic (Probiotic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02044965 — Phase 1 & 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has there been previous research into the combination of probiotics and antibiotics?

"Currently, there are zero Phase 3 trials being conducted for the combination of probiotics and antibiotics. However, three studies in total throughout three different locations - all situated in Shanghai - remain active."

Answered by AI

What is the participant capacity of this trial?

"Affirmative. Clinicaltrials.gov confirms that, first posted on January 1st 2015, this trial is currently accepting applicants. As such, 36 patients need to be identified from one medical centre for participation in the research."

Answered by AI

Does this research endeavor involve individuals aged 35 or higher?

"This specific trial is looking for adolescents aged between 12 and 17. External research indicates that 217 trials are currently recruiting minors, while 647 clinical studies are actively enrolling patients above the age of 65."

Answered by AI

Are there any unfilled slots for participants in this experiment?

"Affirmative. The clinicaltrial.gov portal demonstrates that this medical trial began on January 1, 2015 and was recently updated in September 2021. Currently, 36 participants are required from one site to participate in the study."

Answered by AI

Who meets the eligibility criteria for this research program?

"Candidates must meet the criteria of having a urinary tract infection and fall within an age range of 12 to 17 in order to be eligible for this trial, which is aiming to recruit 36 participants."

Answered by AI

Is this particular trial a pioneering endeavor?

"Research into the efficacy of probiotics plus antibiotic has been conducted since 2015, when a study sponsored by Canadian Urological Association was completed with 36 participants. After receiving Phase 1 & 2 approval for its drug status, there are currently 3 active trials for this medication in three different countries spanning two cities."

Answered by AI

Who else is applying?

What state do they live in?
Maryland
California
How old are they?
18 - 65
65+
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
What site did they apply to?
London Health Sciences Centre
Recent research and studies
clinicaltrials.govStudy
Can Probiotics be Used in the Prevention of Recurrent UTI in Paediatric Neurogenic Bladder
Dr. Sumit Dave 2015. "Can Probiotics be Used in the Prevention of Recurrent UTI in Paediatric Neurogenic Bladder". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02044965.
All > Uti
~3 spots leftby May 2025
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