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Non-invasive Brain Stimulation
rTMS for Memory Enhancement
N/A
Recruiting
Research Sponsored by University of Pennsylvania
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
18-60 years old
Normal cognition
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, after approx. 1 month, after approx. 2 months
Awards & highlights
Study Summary
This trial is investigating how to better target transcranial magnetic stimulation (TMS) to improve working memory by using each person's individual brain states from functional magnetic resonance imaging (fMRI).
Who is the study for?
This trial is for right-handed individuals aged 18-60 with normal cognition and no psychiatric, neurological disorders, or traumatic brain injuries. Participants must not be on psychoactive medications, have a history of stroke or epilepsy, color blindness, implanted devices like pacemakers, or conditions preventing MRI scans.Check my eligibility
What is being tested?
The study tests if working memory can be enhanced using individualized repetitive Transcranial Magnetic Stimulation (rTMS) guided by each participant's unique fMRI data to determine the best stimulation frequencies for improving memory function.See study design
What are the potential side effects?
While rTMS is generally considered safe, potential side effects may include headache, scalp discomfort at the stimulation site, tingling or spasms in facial muscles, lightheadedness and rare risk of seizure.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am between 18 and 60 years old.
Select...
My thinking and memory skills are normal.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline, after approx. 1 month, after approx. 2 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, after approx. 1 month, after approx. 2 months
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Effect 'Optimal' vs 'Least-Optimal' rTMS frequency on the Delayed Match to Sample Task
Effect of different TMS frequencies on N-back performance
Secondary outcome measures
Change in Working Memory Performance after rTMS in the scanner
Working Memory Performance in Behavior Sessions
Working Memory Performance in MRI Sessions
Trial Design
2Treatment groups
Experimental Treatment
Group I: Sub-Optimal TMS Frequency, Then Optimized TMS frequencyExperimental Treatment1 Intervention
In the first neuromodulation session, participants will receive rTMS using their sub-optimal TMS frequency. After washout period of 1 week (minimum), the participants will start their second neuromodulation session using their optimal TMS frequency instead.
Group II: Optimized TMS frequency, Then Sub-Optimal TMS FrequencyExperimental Treatment1 Intervention
In the first neuromodulation session, participants will receive rTMS using their optimal TMS frequency. After washout period of 1 week (minimum), the participants will start their second neuromodulation session using their sub-optimal TMS frequency instead.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Repetitive Transcranial Magnetic Stimulation (rTMS)
2019
Completed Phase 2
~780
Find a Location
Who is running the clinical trial?
University of PennsylvaniaLead Sponsor
2,012 Previous Clinical Trials
42,897,171 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I cannot have an MRI or have a condition that affects MRI results.I have a history of a serious neurological disorder or traumatic brain injury.I have a history of stroke, epilepsy, or brain scarring.I am between 18 and 60 years old.I understand the study and can follow its procedures.My thinking and memory skills are normal.I have not had any serious brain injuries or neurological disorders.I am not taking any psychoactive medications.You have never been diagnosed with any mental health conditions listed in the DSM-V.
Research Study Groups:
This trial has the following groups:- Group 1: Optimized TMS frequency, Then Sub-Optimal TMS Frequency
- Group 2: Sub-Optimal TMS Frequency, Then Optimized TMS frequency
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Memory Patient Testimony for trial: Trial Name: NCT04402294 — N/A
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Which type of person would be best-fit to help with this research?
"This study is looking for 38 individuals that fit the following description: between 18 and 60 years old, right-handed, no DSM-V diagnosis, no history of neurological disorders (aside from mild TBI), no current psychoactive medication use, normal cognition, and female patients must not be pregnant."
Answered by AI
Does this research project accept volunteers who are under the age of 65?
"This study only enrolls individuals that are aged 18-60, as stipulated in the inclusion criteria."
Answered by AI
Who else is applying?
What state do they live in?
New Jersey
Pennsylvania
What site did they apply to?
University of Pennsylvania
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0
Why did patients apply to this trial?
After seeing a family friend deal with memory loss issues in the last few years, I've had an interest in joining research studies to further scientific understanding on memory loss. I hope it can help others in the future.
PatientReceived 1 prior treatment
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