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DST-2970 (Abiraterone) for Prostate Cancer
Study Summary
This trial is a Phase I study to test the safety and effectiveness of a new drug, DST-2970, in prostate cancer patients who have developed resistance to abiraterone acetate, a standard hormone therapy. The study will include a dose escalation phase followed by a dose expansion phase.
- Prostate Cancer
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Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
Frequently Asked Questions
Are new participants being admitted to this research endeavor?
"Clinicaltrials.gov states that this research program is currently in search of volunteers; its first appearance was on January 31st 2020, and it has recently been updated as of July 5th 2022."
How many participants is this research endeavor recruiting?
"In order to move forward with this clinical trial, 54 suitable participants need to be enrolled. Potential enrollees can take part in the study at either University of Miami (Miami, Florida) or Icahn School of Medicine at Mount Sinai (New york, New York)."
In what geographical areas is this research available?
"Patients may take part in this clinical trial at various institutions, including the University of Miami (Miami), Icahn School of Medicine at Mount Sinai (New york) and Carolina Urologic Research Center (Myrtle Beach). Additional sites are available."
Is there any risk associated with administering DST-2970 (Abiraterone)?
"The safety of DST-2970 (Abiraterone) is rated as a 1 due to the limited evidence available from Phase 1 trials, which do not provide substantial proof for either efficacy or safety."
Are there any other experiments that have been conducted regarding the use of DST-2970 (Abiraterone)?
"As of now, 366 clinical trials researching DST-2970 (Abiraterone) are in progress. Of those, 100 have entered Phase 3 and the majority can be found near Duarte in California. Simultaneously, 1742 locations around the globe are running Abiraterone studies."
In what circumstances is DST-2970 (Abiraterone) typically prescribed?
"DST-2970 (Abiraterone) is typically prescribed for patients suffering from thyroiditis. Its therapeutic effects can also be leveraged to manage other diseases, including ulcerative colitis, neoplastic conditions, and varicella-zoster virus induced acute retinal necrosis."
What is the ultimate objective of this experiment?
"This multi-phase medical trial, lasting for up to 18 months, will focus on Dose-Limiting Toxicity as a primary metric. The secondary objectives are measuring the efficacy of DST-2970 using modified RECIST 1.1 via Time to Progression (rTTP) and Change in Tumor Size assessments; additionally, trough levels at C1hour, C2hour and C3hour following daily oral administration of abiraterone will be monitored through Pharmacokinetic analysis."
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