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Steroid Synthesis Inhibitor

DST-2970 (Abiraterone) for Prostate Cancer

Phase 1
Waitlist Available
Research Sponsored by DisperSol Technologies, LLC
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12-18 months
Awards & highlights

Study Summary

This trial is a Phase I study to test the safety and effectiveness of a new drug, DST-2970, in prostate cancer patients who have developed resistance to abiraterone acetate, a standard hormone therapy. The study will include a dose escalation phase followed by a dose expansion phase.

Eligible Conditions
  • Prostate Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12-18 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12-18 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Dose-Limiting Toxicity
Maximum-tolerated dose (MTD)
Recommended Phase II dose (RP2D)
Secondary outcome measures
Body Weight Changes
Change in Tumor Size
Duration of response (DoR)
+3 more
Other outcome measures
Exploration of potential biomarkers

Trial Design

1Treatment groups
Experimental Treatment
Group I: Prostate CancerExperimental Treatment3 Interventions
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Abiraterone Acetate
2015
Completed Phase 4
~1880

Find a Location

Who is running the clinical trial?

DisperSol Technologies, LLCLead Sponsor
1 Previous Clinical Trials
25 Total Patients Enrolled
Translational Drug DevelopmentOTHER
18 Previous Clinical Trials
958 Total Patients Enrolled
1 Trials studying Prostate Cancer
23 Patients Enrolled for Prostate Cancer

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are new participants being admitted to this research endeavor?

"Clinicaltrials.gov states that this research program is currently in search of volunteers; its first appearance was on January 31st 2020, and it has recently been updated as of July 5th 2022."

Answered by AI

How many participants is this research endeavor recruiting?

"In order to move forward with this clinical trial, 54 suitable participants need to be enrolled. Potential enrollees can take part in the study at either University of Miami (Miami, Florida) or Icahn School of Medicine at Mount Sinai (New york, New York)."

Answered by AI

In what geographical areas is this research available?

"Patients may take part in this clinical trial at various institutions, including the University of Miami (Miami), Icahn School of Medicine at Mount Sinai (New york) and Carolina Urologic Research Center (Myrtle Beach). Additional sites are available."

Answered by AI

Is there any risk associated with administering DST-2970 (Abiraterone)?

"The safety of DST-2970 (Abiraterone) is rated as a 1 due to the limited evidence available from Phase 1 trials, which do not provide substantial proof for either efficacy or safety."

Answered by AI

Are there any other experiments that have been conducted regarding the use of DST-2970 (Abiraterone)?

"As of now, 366 clinical trials researching DST-2970 (Abiraterone) are in progress. Of those, 100 have entered Phase 3 and the majority can be found near Duarte in California. Simultaneously, 1742 locations around the globe are running Abiraterone studies."

Answered by AI

In what circumstances is DST-2970 (Abiraterone) typically prescribed?

"DST-2970 (Abiraterone) is typically prescribed for patients suffering from thyroiditis. Its therapeutic effects can also be leveraged to manage other diseases, including ulcerative colitis, neoplastic conditions, and varicella-zoster virus induced acute retinal necrosis."

Answered by AI

What is the ultimate objective of this experiment?

"This multi-phase medical trial, lasting for up to 18 months, will focus on Dose-Limiting Toxicity as a primary metric. The secondary objectives are measuring the efficacy of DST-2970 using modified RECIST 1.1 via Time to Progression (rTTP) and Change in Tumor Size assessments; additionally, trough levels at C1hour, C2hour and C3hour following daily oral administration of abiraterone will be monitored through Pharmacokinetic analysis."

Answered by AI
~10 spots leftby May 2025