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Interleukin

Dupilumab for Atopic Dermatitis

Phase < 1
Waitlist Available
Led By Elena Anna De Filippis, MD, PhD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline
Awards & highlights

Study Summary

This trial looks at the role of eosinophils (a type of white blood cell) in immunity and metabolism, specifically in obesity and insulin resistance.

Eligible Conditions
  • Atopic Dermatitis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Homa IR
Matsuda Index
Secondary outcome measures
Adipo-IR
Adipokines
Fasting Free Fatty Acid
+1 more

Side effects data

From 2021 Phase 4 trial • 188 Patients • NCT04033367
12%
Accidental Overdose
2%
Conjunctivitis
2%
Nasopharyngitis
2%
Headache
2%
Dermatitis Atopic
1%
Fall
1%
Multiple Fractures
100%
80%
60%
40%
20%
0%
Study treatment Arm
OLE Period: Dupilumab/Dupilumab
DB Period: Placebo
DB Period: Dupilumab
OLE Period: Placebo/Dupilumab

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Subjects on DupilumabExperimental Treatment1 Intervention
individuals with atopic dermatitis placed on dupilumab for more than 6 months will be eligible to this study. Their metabolic profile will be compared to the group of "Subjects on Phototherapy"
Group II: Subjects on PhototherapyActive Control1 Intervention
individuals with atopic dermatitis placed on phototherapy for more than 6 months will be eligible to this study to serve as an active comparator to the "Subjects with Dupilumab"
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Dupilumab
2017
Completed Phase 4
~12230

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,227 Previous Clinical Trials
3,771,661 Total Patients Enrolled
Elena Anna De Filippis, MD, PhDPrincipal InvestigatorMayo
1 Previous Clinical Trials
28 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any vacancies remaining for participation in this clinical trial?

"Data available on clinicaltrials.gov suggests that this medical trial is actively looking for participants. It was initially posted on August 9th 2022, and the information therein has been most recently modified as of September 29th 2022."

Answered by AI

What is the current enrollment of this clinical investigation?

"That is accurate. Per the information found on clinicaltrials.gov, this investigation was first posted in August of 2022 and most recently updated on September 29th 2022; it is currently searching for 24 participants to be enrolled at a single medical facility."

Answered by AI

What outcomes is the research hoping to observe?

"This scientific inquiry will measure its baseline efficacy by evaluating Homa IR. Secondary markers of success include systemic inflammatory biomarkers (IL1, TNFa, hs-CRP, MCP1, IL-6, IL-4 and IL13), adipokines (leptin and adiponectin) along with fasting free fatty acid levels to be evaluated during an OGTT."

Answered by AI

Are any adolescents being enrolled in this research experiment?

"According to the inclusion criteria, this trial is available for individuals aged 18 to 60. Alternatively, there are 127 trials open specifically to patients under 18 and 257 other studies targeting those over 65 years old."

Answered by AI

Is it feasible for me to take part in this experiment?

"This clinical trial requires 24 participants between the ages of 18 and 60 who have been diagnosed with insulin resistance. To be eligible, they must possess a BMI ranging from 22-29 kg/m^2, have taken dupilumab treatment for more than 6 months, or can verify that they used topical steroids or phototherapy to manage their Atopic dermatitis. Furthermore, all applicants are required to sign an informed consent form prior to enrollment."

Answered by AI
~3 spots leftby May 2025