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Brain Stimulation + Gait Training for Stroke Recovery

N/A
Recruiting
Led By Sangeetha Madhavan
Research Sponsored by University of Illinois at Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age greater than 18 years
Walking speed lesser than 1.2 m/s
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline to immediately after training and baseline to 3 months follow up
Awards & highlights

Study Summary

This trial is testing a brain stimulation protocol to improve walking outcomes in people with stroke. The goal is to understand the neural mechanisms associated with response to the intervention.

Who is the study for?
This trial is for adults who've had their first stroke more than 3 months ago, can walk at least 5 minutes with or without a walking aid but slower than 1.2 m/s, and have some movement in the affected leg. They shouldn't have severe muscle stiffness, major heart or lung diseases, certain mental impairments, skin conditions worsened by stimulation, metal head implants, pacemakers, recent concussions or be pregnant.Check my eligibility
What is being tested?
The study tests if brain stimulation combined with ankle exercises and high-speed treadmill training improves walking after a stroke. It also looks into how the brain changes with this treatment. Participants will receive transcranial direct current stimulation (tDCS) alongside physical therapy interventions.See study design
What are the potential side effects?
Possible side effects include mild discomfort or itching under the electrode during tDCS; fatigue from physical exercises; and risks associated with intense exercise like shortness of breath or increased heart rate.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am older than 18 years.
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I walk slower than 1.2 meters per second.
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I can move my ankle upwards at least 5 degrees.
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I have difficulty walking due to partial paralysis.
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My leg movement is moderately impaired.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline to immediately after training and baseline to 3 months follow up
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline to immediately after training and baseline to 3 months follow up for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Walking speed with 10 meter walk test
Secondary outcome measures
Aerobic capacity
Ankle motor control
Ankle range of motion
+12 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Priming+HIISTTExperimental Treatment3 Interventions
Facilitatory transcranial direct current stimulation (tDCS) and ankle motor training before high intensity interval speed based treadmill training
Group II: Sham+HIISTTPlacebo Group1 Intervention
Sham tDCS before high intensity interval speed based treadmill training

Find a Location

Who is running the clinical trial?

University of Illinois at ChicagoLead Sponsor
613 Previous Clinical Trials
1,560,892 Total Patients Enrolled
18 Trials studying Stroke
2,187 Patients Enrolled for Stroke
University of Maryland, College ParkOTHER
157 Previous Clinical Trials
46,015 Total Patients Enrolled
6 Trials studying Stroke
564 Patients Enrolled for Stroke
Northwestern UniversityOTHER
1,601 Previous Clinical Trials
915,564 Total Patients Enrolled
31 Trials studying Stroke
25,135 Patients Enrolled for Stroke

Media Library

High intensity interval speed based treadmill training (HIISTT) Clinical Trial Eligibility Overview. Trial Name: NCT04477330 — N/A
Stroke Research Study Groups: Priming+HIISTT, Sham+HIISTT
Stroke Clinical Trial 2023: High intensity interval speed based treadmill training (HIISTT) Highlights & Side Effects. Trial Name: NCT04477330 — N/A
High intensity interval speed based treadmill training (HIISTT) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04477330 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there vacancies available for patient enrolment in this clinical trial?

"Affirmative. According to the information showcased on clinicaltrials.gov, this medical trial is actively enrolling new patients for research purposes. This experiment was initially launched on September 1st 2020 and has recently been modified on June 2nd 2022. 100 individuals are necessary in order to conduct the study from a solitary site."

Answered by AI

Do I fulfill the criteria to participate in this research initiative?

"This medical study seeks out 100 individuals aged 18 to 80 who have suffered a single stroke over 3 months ago and are still living with residual hemiparetic gait deficits. To qualify, these patients must possess the ability to walk for 5 minutes at their own pace (using handheld assistive device if needed) as well as maintain walking speed lower than 1.2 meters per second; additionally, they should demonstrate between 15-30 points on the Lower Limb Fugl-Meyer Motor score and present at least five degrees of ankle dorsiflexion necessary in order to complete an ankle tracking task."

Answered by AI

What is the maximum number of participants allowed in this clinical trial?

"Affirmative. Clinicaltrials.gov data reveals that participant recruitment for this trial is ongoing - the study was first posted on September 1st 2020 and recently edited June 2nd 2022. A total of 100 individuals will be enrolled at one site."

Answered by AI

Does this trial include adult participants aged 18 and over?

"For this research, the age criteria for inclusion is between 18 to 80 years old. For minors under 18 and senior citizens over 65, there are 37 studies and 1006 studies respectively."

Answered by AI
~30 spots leftby Dec 2025