Your session is about to expire
← Back to Search
Deep Brain Stimulation for Parkinson's Disease
Study Summary
This trial is testing a new way to use deep brain stimulation to improve gait function in patients with Parkinson's disease. Ten patients will have electrodes implanted in their brains to record and stimulate activity in the areas involved in walking. The goal is to develop an adaptive stimulation paradigm to selectively stimulate the pallidum (a brain structure) during different phases of the gait cycle and measure improvements in gait parameters.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
Find a Location
Who is running the clinical trial?
Media Library
- I or my caregiver can recharge the medical device as needed.I have chosen to undergo deep brain stimulation surgery for my condition.I have had brain surgery before.I need treatments like ECT, rTMS, or diathermy for my condition.My oral medication for movement issues hasn't worked well, as confirmed by a specialist.You have a history of using drugs or alcohol in a harmful way.I do not have any medical conditions that increase my risk for surgery complications.I am between 21 and 75 years old.I don't have any movement issues that would stop me from having surgery.I have Parkinson's with mild thinking or memory problems.My Parkinson's disease causes severe tremors not improved by medication.My Parkinson's symptoms improve by 30% with medication, and I have good periods lasting at least 2 hours without severe involuntary movements.You have a medical device implanted in your body like a cochlear implant, pacemaker, defibrillator, or neurostimulator.I have been diagnosed with Parkinson's disease for over 3 years.You have movement symptoms that go away when someone suggests it or when you're not being watched, or your symptoms don't match up with your medical condition. You also show other signs of faking symptoms or having a lot of unexplained physical problems or mental health issues.You have severe untreated depression or have a history of trying to harm yourself or are currently thinking about doing so.My movement disorder is severe enough to need surgery despite medication.You are allergic to the materials used in the implantable device, like titanium, polyurethane, silicone, and nylon.I have difficulty walking or keeping my balance without medication.You can't have major problems with memory or thinking.
- Group 1: Open-loop deep brain stimulation
- Group 2: Randomized deep brain stimulation
- Group 3: Deep brain stimulation during contralateral limb movement
- Group 4: Deep brain stimulation during contralateral limb rest
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are there any vacancies available for potential participants in this experiment?
"As per clinicaltrials.gov, this trial is no longer engaging with potential participants; the initial post-date was June 15th 2021 and it last updated on October 4th 2022. However, there are still plenty of other medical studies that need volunteers at present – 483 to be exact!"
Who is eligible to participate in this research endeavor?
"This investigation is looking for 10 individuals with Parkinson's disease aged between 18 and 75. Necessary criteria includes: movement disorder issues that necessitate the surgical implantation of deep brain stimulators, patient requesting surgery to address their condition, no motion-related abnormalities hinting at an alternative diagnosis or contraindicating medical procedure, capacity to adhere to study follow-up visits for neurological recording, testing of adaptive stimulation, and clinical evaluation., age range 21 -75 years old , inadequate relief from conventional medication as judged by a neurologist specialising in motor disorders , absence of significant cognitive impairment (score of 21 or higher on Montreal Cognitive Assessment"
Is enrollment open to those aged 70 or above for this trial?
"Participants of this clinical trial must be over 18 years old, yet younger than 75."
What aims are the researchers hoping to achieve from this investigation?
"According to Burroughs Wellcome, the primary outcome that will be evaluated in this trial across a two year span is motor learning task mean accuracy with closed-loop compared to open-loop deep brain stimulation (DBS). Additionally, investigators plan on assessing other variables including stride length as measured by Rover and Xsens devices in metres, five times sit to stand test results which are scored based off speed of transition from sitting to standing position and back again, along with MDS-UPDRS III scores ranging from 0 - 72 points."
Share this study with friends
Copy Link
Messenger