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Lifestyle Physical Activity for Metabolic Diseases

N/A
Waitlist Available
Led By Marc T Hamilton, Ph.D.
Research Sponsored by University of Houston
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age must be 18 years or older
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up the change through the completion of an acute fasting period, approximately 8-12 hours
Awards & highlights

Study Summary

This trial is designed to study the effects of a new way of doing light physical activity - what we are calling "lifestyle physical activity" (LPA) - on specific and systemic metabolism. LPA is designed to be safe and practical for people to do every day, for prolonged periods of time throughout the day, and to be done while performing their daily activities.

Who is the study for?
This trial is for adults over 18 who can fast overnight, maintain consistent diet, medication, and sleep habits. They should have a sedentary lifestyle but be willing to wear activity monitors and not start new diets or exercise programs during the study. Exclusions include practical barriers to participation, current dieting or eating disorders, allergies to lidocaine, pregnancy, use of anticoagulants, or plans to change lifestyle.Check my eligibility
What is being tested?
The trial aims to develop a method that allows people with sedentary lifestyles to sustain muscle activity via oxidative metabolism for extended periods (hours daily). It involves controlled muscular exercises focusing on specific muscles like the soleus in the leg and measuring their biological response without causing fatigue.See study design
What are the potential side effects?
Since this trial focuses on light physical activities designed for unfit individuals leading sedentary lives, side effects are expected to be minimal. However, typical exercise-related discomforts such as mild muscle soreness may occur.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am 18 years old or older.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~the change through the completion of an acute fasting period, approximately 8-12 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and the change through the completion of an acute fasting period, approximately 8-12 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Angiopoietin-like protein 4
Change in postprandial glucose regulation
Change in very low density lipoprotein (VLDL) - Triglyceride
+3 more
Secondary outcome measures
Change in the concentration of GlycA (this is not an acronym; it is a biomarker of inflammation)
Complement component 3 (C3) concentration change
Electrical activity of muscle, Electromyography (EMG)
+9 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Muscular ExerciseExperimental Treatment1 Intervention
Increased level of low effort muscular activity

Find a Location

Who is running the clinical trial?

University of HoustonLead Sponsor
147 Previous Clinical Trials
47,418 Total Patients Enrolled
1 Trials studying Physical Inactivity
257 Patients Enrolled for Physical Inactivity
American Diabetes AssociationOTHER
139 Previous Clinical Trials
99,546 Total Patients Enrolled
Marc T Hamilton, Ph.D.Principal InvestigatorUniversity of Houston

Media Library

Muscular Exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT05135234 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are researchers looking for participants in this experiment at the moment?

"Clinicaltrials.gov states that this trial has concluded its recruitment efforts, with the original post date being August 1st 2016 and the last update on November 19th 2021. Although participation in this study is no longer possible, 1199 other clinical trials are currently accepting participants."

Answered by AI

What are the primary goals of this research endeavor?

"This clinical trial's main aim is to measure the alteration in sedentary muscle time due to a single bout of contractile activity from the soleus. Secondary objectives involve observing changes in ferritin concentration (a biomarker linked with diabetes and inflammation), apolipoprotein B100 concentration, and electromyography results for triceps surae activation following an 8-12 hour fast."

Answered by AI

Who else is applying?

What state do they live in?
Texas
What site did they apply to?
University of Houston
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0

Why did patients apply to this trial?

I have high cholesterol and some weight issues and would like to learn more and have more mobility. Please consider me.
PatientReceived 2+ prior treatments

What questions have other patients asked about this trial?

Will I be charged for this trial?
PatientReceived 1 prior treatment
Recent research and studies
clinicaltrials.govStudy
Developing a Physiological Understanding of High Duration Activity
Marc Hamilton 2016. "Developing a Physiological Understanding of High Duration Activity". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05135234.
~10 spots leftby Dec 2025
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